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    zp2.6 zona pellucida glycoprotein 2, tandem duplicate 6 [ Danio rerio (zebrafish) ]

    Gene ID: 114440, updated on 4-Jan-2025

    Summary

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    Official Symbol
    zp2.6provided by ZNC
    Official Full Name
    zona pellucida glycoprotein 2, tandem duplicate 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090306-2
    See related
    Ensembl:ENSDARG00000091409 AllianceGenome:ZFIN:ZDB-GENE-090306-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zp2; zp2c; zp2.4; fc33d01; zgc:111913; zgc:111918
    Summary
    Predicted to enable acrosin binding activity. Predicted to be a structural constituent of egg coat. Predicted to be involved in binding activity of sperm to zona pellucida and prevention of polyspermy. Predicted to act upstream of or within single fertilization. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in collagen-containing extracellular matrix and egg coat. Is expressed in ovary. Orthologous to several human genes including ZP4 (zona pellucida glycoprotein 4). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See zp2.6 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (54304800..54306651)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (54435228..54436906)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene zona pellucida glycoprotein 2, tandem duplicate 3 Neighboring gene si:zfos-1505d6.3 Neighboring gene zona pellucida glycoprotein 2, tandem duplicate 1 Neighboring gene zona pellucida glycoprotein 2, tandem duplicate 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of housekeeping genes suitable for gene expression analysis in the zebrafish. Casadei R, et al. Gene Expr Patterns, 2011 Mar-Apr. PMID 21281742
    2. Regulation of zebrafish zona pellucida gene activity in developing oocytes. Mold DE, et al. Biol Reprod, 2009 Jul. PMID 19299318
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63627, MGC111913

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acrosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of egg coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prevention of polyspermy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within single fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in egg coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zona pellucida glycoprotein 2, tandem duplicate 6
    Names
    zona pellucida glycoprotein 2, tandem duplicate 4
    zona pellucida glycoprotein 2.4
    zona pellucida glycoprotein 2.6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131829.2 → NP_571904.2  zona pellucida glycoprotein 2, tandem duplicate 6 precursor

      Status: VALIDATED

      Source sequence(s)
      CU914156
      UniProtKB/TrEMBL
      A0A8M1PCA2, F1QJ26
      Related
      ENSDARP00000109385.2, ENSDART00000121661.3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      54304800..54306651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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