nanos1 nanos homolog 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nanos1provided by ZNC
Official Full Name: nanos homolog 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1623
See related: Ensembl:ENSDARG00000109337 AllianceGenome:ZFIN:ZDB-GENE-030131-1623
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb76c12; fb93h11; fb98e07; wu:fb76c12; wu:fb93h11; wu:fb98e07; wu:fq21a10
Summary: Predicted to enable mRNA binding activity and translation repressor activity. Predicted to be involved in negative regulation of translation and oogenesis. Predicted to act upstream of or within regulation of translation. Located in germ plasm and perinuclear region of cytoplasm. Is expressed in blastomere; cerebellum; hindbrain; midbrain hindbrain boundary; and primordial germ cell. Human ortholog(s) of this gene implicated in spermatogenic failure 12. Orthologous to human NANOS1 (nanos C2HC-type zinc finger 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (5117072..5119497)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (4810238..4812663)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that nanos3 function is required for the maintenance of germline stem cell (GSC), but not for their specification, and suggest that nanos2 and nanos3 are partially redundant in this role.
Title: nanos3 maintains germline stem cells and expression of the conserved germline stem cell gene nanos2 in the zebrafish ovary.

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General gene information

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Markers

fb93h11.x1 (e-PCR)
- UniSTS:203545

fb76c12.x1 (e-PCR)
- UniSTS:187513

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables translation repressor activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in oogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in germ plasm	IDA Inferred from Direct Assay more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: nanos homolog 1

Names: nanos-related; nos2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.