cdkn1ca cyclin dependent kinase inhibitor 1Ca [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cdkn1caprovided by ZNC
Official Full Name: cyclin dependent kinase inhibitor 1Caprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040123-1
See related: Ensembl:ENSDARG00000010878 AllianceGenome:ZFIN:ZDB-GENE-040123-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb961; cdkn1c; p27Xic1-a; zgc:86618
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity. Acts upstream of or within cell fate specification; glial cell differentiation; and negative regulation of mitotic cell cycle. Predicted to be located in nucleus. Is expressed in several structures, including mesoderm; muscle; nervous system; neural tube; and notochord. Human ortholog(s) of this gene implicated in Beckwith-Wiedemann syndrome; IMAGe syndrome; and hyperinsulinism. Orthologous to human CDKN1C (cyclin dependent kinase inhibitor 1C). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (48663666..48665155, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (48390890..48392379, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myod in turn up-regulates cdkn1c, thereby providing a positive feedback loop that switches myogenic cells to terminal differentiation
Title: Cdkn1c drives muscle differentiation through a positive feedback loop with Myod.
during late embryogenesis, neural cells that have low but functional levels of Cdkn1c, regulated by Notch activity, are specified for oligodendrocyte fate
Title: Oligodendrocyte specification in zebrafish requires notch-regulated cyclin-dependent kinase inhibitor function.
p57Kip2 is both necessary and sufficient to mediate Shh-induced cell-cycle exit in the deveoping zebrafish retina.
Title: Shh directs cell-cycle exit by activating p57Kip2 in the zebrafish retina.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cyclin dependent kinase inhibitor 1Ca

Names: cyclin-dependent kinase inhibitor 1C (p57, Kip2); p57kip2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.