spsb4a splA/ryanodine receptor domain and SOCS box containing 4a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: spsb4aprovided by ZNC
Official Full Name: splA/ryanodine receptor domain and SOCS box containing 4aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070911-3
See related: Ensembl:ENSDARG00000016084 AllianceGenome:ZFIN:ZDB-GENE-070911-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: spsb4; ssb-4; wu:fb38e11; si:dkeyp-90g12.2
Summary: Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in brain; head; and reproductive system. Orthologous to human SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (39584071..39726836, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (39618430..39761169, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SSB-1 and -4 transcripts were present in all blastomeres during the early embryonic stages, but the genes differ in their expression pattern. SSB-4 mRNA was located in the region of the primordial germ cells in 24 and 72 hpf embryos
Title: Cloning and characterization of the SSB-1 and SSB-4 genes expressed in zebrafish gonads.

Submit: New GeneRIF Correction

General gene information

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Markers

fb38e11 (e-PCR)
- UniSTS:187158

fc02e07.y1 (e-PCR)
- UniSTS:192072

fb38e11.x1 (e-PCR)
- UniSTS:203172

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SPRY domain-containing SOCS box protein 4a

Names: splA/ryanodine receptor domain and SOCS box containing 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256642.1 → NP_001243571.1 SPRY domain-containing SOCS box protein 4a

See identical proteins and their annotated locations for NP_001243571.1

Status: VALIDATED

Source sequence(s)

BX322588, BX677675

UniProtKB/TrEMBL

A0A8M1NZK5, B0S5W3

Related

ENSDARP00000112876.1, ENSDART00000147821.2

Conserved Domains (2) summary

cd03718
Location:236 → 277

SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...

cd12906
Location:55 → 231

SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

39584071..39726836 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005171293.5 → XP_005171350.1 SPRY domain-containing SOCS box protein 4a isoform X1

See identical proteins and their annotated locations for XP_005171350.1

UniProtKB/TrEMBL

A0A8M1NZK5, B0S5W3

Conserved Domains (2) summary

cd03718
Location:236 → 277

SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...

cd12906
Location:55 → 231

SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)