U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Asap ArfGAP with SH3 domain, ankyrin repeat and PH domain [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35783, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Asapprovided by FlyBase
    Official Full Name
    ArfGAP with SH3 domain, ankyrin repeat and PH domainprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050372
    Locus tag
    Dmel_CG30372
    See related
    AllianceGenome:FB:FBgn0050372
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ASAP; Asap1; ASAP1; CG14758; CG2226; CG30372; dAsap; Dmel\CG30372
    Summary
    Predicted to enable GTPase activator activity and phosphatidylinositol phosphate binding activity. Involved in several processes, including compound eye morphogenesis; mitotic cleavage furrow ingression; and regulation of Golgi organization. Located in apical part of cell and cytoplasm. Colocalizes with adherens junction; nucleus; and plasma membrane. Is expressed in adult head. Orthologous to several human genes including ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Asap in Genome Data Viewer
    Location:
    44B2-44B2; 2-58 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8114286..8123001, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4001791..4010506, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Transmembrane protein 63 Neighboring gene Cullin 4 Neighboring gene under-developed Neighboring gene Nucleoporin 50kD Neighboring gene coilin Neighboring gene Suppressor of Cytokine Signaling at 44A Neighboring gene uncharacterized protein Neighboring gene PSEA-binding protein 49kD

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Arf GAP Asap promotes Arf1 function at the Golgi for cleavage furrow biosynthesis in Drosophila. Rodrigues FF, et al. Mol Biol Cell, 2016 Oct 15. PMID 27535433, Free PMC Article
    2. Motivation, Perception, and Chance Converge to Make a Binary Decision. Zhang SX, et al. Neuron, 2018 Jul 25. PMID 29983326, Free PMC Article
    3. Ancient complexity, opisthokont plasticity, and discovery of the 11th subfamily of Arf GAP proteins. Schlacht A, et al. Traffic, 2013 Jun. PMID 23433073, Free PMC Article
    4. Drosophila as a Potential Model for Ocular Tumors. Bennett D, et al. Ocul Oncol Pathol, 2015 Apr. PMID 27172095, Free PMC Article
    5. Changes in rRNA transcription influence proliferation and cell fate within a stem cell lineage. Zhang Q, et al. Science, 2014 Jan 17. PMID 24436420, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Asap forms a physical complex with Cindr.
      Title: Role for a Cindr-Arf6 axis in patterning emerging epithelia.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables phosphatidylinositol phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cleavage furrow ingression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ArfGAP with SH3 domain, ankyrin repeat and PH domain
    Names
    ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
    Asap-PB
    Asap-PC
    Asap-PD
    CG30372-PB
    CG30372-PC
    CG30372-PD

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8114286..8123001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169614.2 → NP_001163085.1  ArfGAP with SH3 domain, ankyrin repeat and PH domain, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163085.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z7A6
      Conserved Domains (8) summary
      cd07604
      Location:35 → 249
      BAR_ASAPs; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing proteins
      cd11821
      Location:1067 → 1121
      SH3_ASAP; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing proteins
      cd00204
      Location:572 → 684
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:302 → 410
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:311 → 404
      PH; PH domain
      pfam01412
      Location:427 → 542
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:554 → 662
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:586 → 622
      ANK; ANK repeat [structural motif]

    2. NM_001299254.1 → NP_001286183.1  ArfGAP with SH3 domain, ankyrin repeat and PH domain, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286183.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEF8
      Conserved Domains (8) summary
      cd07604
      Location:35 → 249
      BAR_ASAPs; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing proteins
      cd11821
      Location:1083 → 1137
      SH3_ASAP; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing proteins
      cd00204
      Location:572 → 684
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:302 → 410
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:311 → 404
      PH; PH domain
      pfam01412
      Location:427 → 542
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:554 → 662
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:586 → 622
      ANK; ANK repeat [structural motif]

    3. NM_001014504.3 → NP_001014504.1  ArfGAP with SH3 domain, ankyrin repeat and PH domain, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014504.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z7A6, E1JH06, Q6AWJ6, Q95R80
      Conserved Domains (6) summary
      cd07604
      Location:35 → 249
      BAR_ASAPs; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing proteins
      cd11821
      Location:1095 → 1149
      SH3_ASAP; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing proteins
      cd13251
      Location:302 → 410
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:586 → 622
      ANK; ANK repeat [structural motif]
      cd08834
      Location:425 → 541
      ArfGap_ASAP; ArfGAP domain of ASAP (Arf GAP, SH3, ANK repeat and PH domains) subfamily of ADP-ribosylation factor GTPase-activating proteins
      pfam12796
      Location:554 → 662
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LEF8 A0A0B4LEF8
    A1Z7A6.1 A1Z7A6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous