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    rad50 rad50 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37564, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rad50provided by FlyBase
    Official Full Name
    rad50provided by FlyBase
    Primary source
    FLYBASE:FBgn0034728
    Locus tag
    Dmel_CG6339
    See related
    AllianceGenome:FB:FBgn0034728
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6339; CG6339; Dmel\CG6339; Dmrad50; dRad50; Rad-50; Rad50; RAD50
    Summary
    Predicted to enable G-quadruplex DNA binding activity; double-stranded telomeric DNA binding activity; and single-stranded telomeric DNA binding activity. Involved in double-strand break repair; protein localization; and telomere maintenance via recombination. Located in condensed chromosome and nucleus. Part of Mre11 complex. Is expressed in several structures, including adult head; anlage in statu nascendi; central brain anlage; central brain anlage in statu nascendi; and ganglia. Human ortholog(s) of this gene implicated in transitional cell carcinoma. Orthologous to human RAD50 (RAD50 double strand break repair protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rad50 in Genome Data Viewer
    Location:
    58E1-58E1; 2-100 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22421013..22425482)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18308518..18312987)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45152 Neighboring gene quaking related 58E-2 Neighboring gene mitochondrial ribosomal protein S29 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pickpocket 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Attenuating the DNA damage response to double-strand breaks restores function in models of CNS neurodegeneration. Tuxworth RI, et al. Brain Commun, 2019. PMID 32954257, Free PMC Article
    2. Disruption of Drosophila Rad50 causes pupal lethality, the accumulation of DNA double-strand breaks and the induction of apoptosis in third instar larvae. Gorski MM, et al. DNA Repair (Amst), 2004 Jun 3. PMID 15135728
    3. E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression. Guarner A, et al. Dev Cell, 2017 Dec 18. PMID 29233476, Free PMC Article
    4. Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis. Gao G, et al. Proc Natl Acad Sci U S A, 2009 Jun 30. PMID 19520832, Free PMC Article
    5. Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans. Chauvin SD, et al. Nat Commun, 2024 Jun 1. PMID 38824133, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Mre11-Rad50-Nbs1 complex mediates the robust recruitment of Polo to DNA lesions during mitosis in Drosophila.
      Title: The Mre11-Rad50-Nbs1 complex mediates the robust recruitment of Polo to DNA lesions during mitosis in Drosophila.
    2. NBS1 interacts with HP1 to ensure genome integrity.
      Title: NBS1 interacts with HP1 to ensure genome integrity.
    3. Study identified a stringent requirement for Mre11-Rad50-Nbs (MRN) function in telomere protection during early embryonic development.
      Title: Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-quadruplex DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables double-stranded telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome organization involved in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance via recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance via recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Mre11 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Mre11 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Mre11 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Mre11 complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in condensed nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rad50
    Names
    CG6339-PD
    CG6339-PE
    rad50-PD
    rad50-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22421013..22425482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259532.2 → NP_001246461.1  rad50, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246461.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7L0, D0Z764
      Conserved Domains (3) summary
      TIGR00606
      Location:2 → 1295
      rad50; rad50
      cd03240
      Location:1203 → 1302
      ABC_Rad50; ATP-binding cassette domain of Rad50
      pfam04423
      Location:669 → 716
      Rad50_zn_hook; Rad50 zinc hook motif

    2. NM_166533.4 → NP_726199.3  rad50, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726199.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B6UXS6, B6UXT1, B6UXT2, B6UXT3, B6UXT4, B6UXT5, B6UXT6, B6UXT7, B6UXT8, B6UXT9, B6UXU1, B6UXU2, B6UXU3, B6UXU4, B6UXU5, B6UXU6, B6UXU7, B6UXU8, B6UXU9, B6UXV0, B6UXV1, B6UXV2, Q86NZ9, Q960E0, Q9W252
      UniProtKB/TrEMBL
      D0Z764
      Conserved Domains (3) summary
      TIGR00606
      Location:2 → 1295
      rad50; rad50
      cd03240
      Location:1203 → 1302
      ABC_Rad50; ATP-binding cassette domain of Rad50
      pfam04423
      Location:669 → 716
      Rad50_zn_hook; Rad50 zinc hook motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7L0 A0A0B4K7L0
    Q9W252.4 Q9W252

    Gene LinkOut

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