adp adipose [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: adpprovided by FlyBase
Official Full Name: adiposeprovided by FlyBase
Primary source: FLYBASE:FBgn0000057
Locus tag: Dmel_CG5124
See related: AllianceGenome:FB:FBgn0000057
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Adp; anon-WO0196371.1; anon-WO0196371.27; anon-WO0196371.3; CG5124; Dmel\CG5124
Summary: Involved in lipid metabolic process; negative regulation of sequestering of triglyceride; and response to desiccation. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in organism. Used to study obesity. Orthologous to human WDTC1 (WD and tetratricopeptide repeats 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 55B9-55B9; 2-84 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18151704..18154060)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14039209..14041565)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the anti-obesity function of adipose (Adp) (worm Y73E7A.9, fly adp, and murine Wdtc1) is conserved from worms to mammals.
Title: Adipose is a conserved dosage-sensitive antiobesity gene.
amino acid sequence of the predicted Adipose (Adp) protein; loss of adp activity causes obesity in Drosophila
Title: Control of triglyceride storage by a WD40/TPR-domain protein.

Submit: New GeneRIF Correction

General gene information

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Markers

Dm0148 (e-PCR)
- UniSTS:22629

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of sequestering of triglyceride	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to desiccation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adipose

Names: CG5124-PA; CG5124-PB; adp-PA; adp-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

18151704..18154060

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_137452.3 → NP_611296.2 adipose, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611296.2

Status: REVIEWED

UniProtKB/TrEMBL

Q29QC9, Q7K7W5

Related

FBpp0085923

Conserved Domains (6) summary

COG2319
Location:59 → 242

WD40; WD40 repeat [General function prediction only]

sd00006
Location:342 → 370

TPR; TPR repeat [structural motif]

pfam13174
Location:415 → 445

TPR_6; Tetratricopeptide repeat

pfam13414
Location:341 → 410

TPR_11; TPR repeat

sd00039
Location:72 → 108

7WD40; WD40 repeat [structural motif]

cl02567
Location:54 → 242

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001299634.1 → NP_001286563.1 adipose, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286563.1

Status: REVIEWED

UniProtKB/TrEMBL

Q29QC9, Q7K7W5

Conserved Domains (6) summary

COG2319
Location:59 → 242

WD40; WD40 repeat [General function prediction only]

sd00006
Location:342 → 370

TPR; TPR repeat [structural motif]

pfam13174
Location:415 → 445

TPR_6; Tetratricopeptide repeat

pfam13414
Location:341 → 410

TPR_11; TPR repeat

sd00039
Location:72 → 108

7WD40; WD40 repeat [structural motif]

cl02567
Location:54 → 242

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...