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    Brd8 Bromodomain containing 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43460, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Brd8provided by FlyBase
    Official Full Name
    Bromodomain containing 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0039654
    Locus tag
    Dmel_CG14514
    See related
    AllianceGenome:FB:FBgn0039654
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14514; dBrd8; Dmel\CG14514
    Summary
    Involved in DNA repair-dependent chromatin remodeling and negative regulation of gene expression. Part of NuA4 histone acetyltransferase complex. Is expressed in spermatozoon. Orthologous to human BRD8 (bromodomain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Brd8 in Genome Data Viewer
    Location:
    99A1-99A1; 3-98 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29223485..29226276)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25049207..25051998)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 gamma Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene uncharacterized protein Neighboring gene Ubiquitin specific protease 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional cofactors display specificity for distinct types of core promoters. Haberle V, et al. Nature, 2019 Jun. PMID 31092928, Free PMC Article
    2. Myc and the Tip60 chromatin remodeling complex control neuroblast maintenance and polarity in Drosophila. Rust K, et al. EMBO J, 2018 Aug 15. PMID 29997178, Free PMC Article
    3. In and out: histone variant exchange in chromatin. Jin J, et al. Trends Biochem Sci, 2005 Dec. PMID 16257529
    4. A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression. Lu J, et al. Proc Natl Acad Sci U S A, 2007 May 29. PMID 17517653, Free PMC Article
    5. Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity. Bailetti AA, et al. Dis Model Mech, 2019 May 30. PMID 31072879, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in DNA repair-dependent chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bromodomain containing 8
    Names
    Brd8-PA
    CG14514-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29223485..29226276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143428.4 → NP_651685.2  bromodomain containing 8 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651685.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T9B8, Q9VAM5
      Related
      FBpp0084763
      Conserved Domains (3) summary
      cd05507
      Location:729 → 833
      Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...
      PHA03249
      Location:402 → 582
      PHA03249; DNA packaging tegument protein UL25; Provisional
      pfam14738
      Location:105 → 188
      PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2XY62 Q2XY62
    Q8T9B8 Q8T9B8
    Q9VAM5 Q9VAM5

    Gene LinkOut

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