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    Aduk Another Drosophila Unc-51-like kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41112, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adukprovided by FlyBase
    Official Full Name
    Another Drosophila Unc-51-like kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037679
    Locus tag
    Dmel_CG8866
    See related
    AllianceGenome:FB:FBgn0037679
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ADUK; CG8866; Dmel\CG8866; dULK3; UNC 51-like
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in autophagy and positive regulation of autophagosome assembly. Located in autophagosome. Is expressed in organism. Orthologous to human ULK3 (unc-51 like kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Aduk in Genome Data Viewer
    Location:
    85D11-85D11; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9332064..9334714, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5157786..5160436, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pasiflora 2 Neighboring gene long non-coding RNA:CR43301

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Atg1-independent induction of autophagy by the Drosophila Ulk3 homolog, ADUK. Braden CR, et al. FEBS J, 2016 Nov. PMID 27717182, Free PMC Article
    2. RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Park J, et al. Nature, 2013 Jun 20. PMID 23719381, Free PMC Article
    3. A genome-wide RNA interference screen reveals that variant histones are necessary for replication-dependent histone pre-mRNA processing. Wagner EJ, et al. Mol Cell, 2007 Nov 30. PMID 18042462
    4. A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Yin Z, et al. Nat Cell Biol, 2013 Jul. PMID 23748611, Free PMC Article
    5. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CG8866 (hereafter 'ADUK')
      Title: Atg1-independent induction of autophagy by the Drosophila Ulk3 homolog, ADUK.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_649882.1
    • another drosophila Unc-51-like kinase, isoform B
    NP_731331.1
    • another drosophila Unc-51-like kinase, isoform A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9332064..9334714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169265.2 → NP_731331.1  uncharacterized protein Dmel_CG8866 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731331.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P98, Q9VHF6
      Related
      FBpp0081533
      Conserved Domains (4) summary
      smart00220
      Location:9 → 265
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd02684
      Location:274 → 348
      MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
      pfam04212
      Location:407 → 472
      MIT; MIT (microtubule interacting and transport) domain
      cl21453
      Location:13 → 264
      PKc_like; Protein Kinases, catalytic domain

    2. NM_141625.3 → NP_649882.1  uncharacterized protein Dmel_CG8866 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649882.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P98, Q8T0L6
      Related
      FBpp0081534
      Conserved Domains (4) summary
      smart00220
      Location:9 → 265
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd02684
      Location:274 → 348
      MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
      cl00299
      Location:407 → 462
      MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
      cl21453
      Location:13 → 264
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86P98 Q86P98
    Q8T0L6 Q8T0L6
    Q9VHF6 Q9VHF6

    Gene LinkOut

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