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    Nmda1 N-methyl-D-aspartate receptor-associated protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36419, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nmda1provided by FlyBase
    Official Full Name
    N-methyl-D-aspartate receptor-associated proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013305
    Locus tag
    Dmel_CG3798
    See related
    AllianceGenome:FB:FBgn0013305
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cDNA2; CG3798; Dmel\CG3798; dNMDARA1; DRONMDA; dTmbim3; NMDA-NR1; NMDA1; NMDARA1
    Summary
    Predicted to enable calcium channel activity. Involved in negative regulation of apoptotic process. Predicted to be active in Golgi apparatus and organelle membrane. Is expressed in several structures, including adult head; embryonic Malpighian tubule; embryonic proventriculus; ganglia; and larval nervous system. Orthologous to human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nmda1 in Genome Data Viewer
    Location:
    49D6-49D7; 2-67 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12877094..12880230, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8764599..8767735, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43469 Neighboring gene antisense RNA:CR43468 Neighboring gene Beta-alanine transporter Neighboring gene Lifeguard Neighboring gene Aspartyl-tRNA synthetase Neighboring gene antisense RNA:CR45141 Neighboring gene vestigial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The putative Drosophila NMDARA1 gene is located on the second chromosome and is ubiquitously expressed in embryogenesis. Pellicena-Pallé A, et al. Biochim Biophys Acta, 1995 Apr 4. PMID 7711078
    2. Effects of memantine on mania-like phenotypes exhibited by Drosophila Shaker mutants. Mocci I, et al. CNS Neurosci Ther, 2023 Jul. PMID 36942502, Free PMC Article
    3. The Evolutionary Conserved Transmembrane BAX Inhibitor Motif (TMBIM) Containing Protein Family Members 5 and 6 Are Essential for the Development and Survival of Drosophila melanogaster. Zhang L, et al. Front Cell Dev Biol, 2021. PMID 34540824, Free PMC Article
    4. Mutations in the predicted aspartyl tRNA synthetase of Drosophila are lethal and function as dosage-sensitive maternal modifiers of the sex determination gene Sex-lethal. Stitzinger SM, et al. Mol Gen Genet, 1999 Feb. PMID 10071220
    5. Lead Modulates trans- and cis-Expression Quantitative Trait Loci (eQTLs) in Drosophila melanogaster Heads. Qu W, et al. Front Genet, 2018. PMID 30294342, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in organelle membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-methyl-D-aspartate receptor-associated protein
    Names
    CG3798-PA
    CG3798-PB
    CG3798-PC
    CG3798-PD
    CG3798-PE
    CG3798-PF
    CG3798-PG
    CG3798-PH
    CG3798-PI
    NMDARA1-like
    Nmda1-PA
    Nmda1-PB
    Nmda1-PC
    Nmda1-PD
    Nmda1-PE
    Nmda1-PF
    Nmda1-PG
    Nmda1-PH
    Nmda1-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12877094..12880230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259360.2 → NP_001246289.1  N-methyl-D-aspartate receptor-associated protein, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246289.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JR91
      Conserved Domains (1) summary
      cd10428
      Location:92 → 309
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    2. NM_078998.4 → NP_523722.1  N-methyl-D-aspartate receptor-associated protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523722.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JRM9
      Related
      FBpp0088816
      Conserved Domains (1) summary
      cd10428
      Location:103 → 320
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    3. NM_165956.3 → NP_725237.1  N-methyl-D-aspartate receptor-associated protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725237.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JR91
      Related
      FBpp0088815
      Conserved Domains (1) summary
      cd10428
      Location:92 → 309
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    4. NM_165959.3 → NP_725240.1  N-methyl-D-aspartate receptor-associated protein, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725240.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95T37
      Related
      FBpp0088817
      Conserved Domains (1) summary
      cd10428
      Location:95 → 312
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    5. NM_001259359.1 → NP_001246288.1  N-methyl-D-aspartate receptor-associated protein, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246288.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JR91
      Conserved Domains (1) summary
      cd10428
      Location:92 → 309
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    6. NM_165958.2 → NP_725239.1  N-methyl-D-aspartate receptor-associated protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725239.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JRM9
      Related
      FBpp0088814
      Conserved Domains (1) summary
      cd10428
      Location:103 → 320
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    7. NM_165957.2 → NP_725238.1  N-methyl-D-aspartate receptor-associated protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725238.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JR91
      Related
      FBpp0088813
      Conserved Domains (1) summary
      cd10428
      Location:92 → 309
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    8. NM_165960.2 → NP_725241.2  N-methyl-D-aspartate receptor-associated protein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725241.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JRM9
      Related
      FBpp0088812
      Conserved Domains (1) summary
      cd10428
      Location:103 → 320
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    9. NM_001274000.1 → NP_001260929.1  N-methyl-D-aspartate receptor-associated protein, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260929.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95T37
      Conserved Domains (1) summary
      cd10428
      Location:95 → 312
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JQ30 Q7JQ30
    Q7JR91 Q7JR91
    Q7JRM9 Q7JRM9
    Q95T37 Q95T37

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