Vha100-4 Vacuolar H[+] ATPase 100kD subunit 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Vha100-4provided by FlyBase
Official Full Name: Vacuolar H[+] ATPase 100kD subunit 4provided by FlyBase
Primary source: FLYBASE:FBgn0038613
Locus tag: Dmel_CG7678
See related: AllianceGenome:FB:FBgn0038613
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7678; Dmel\CG7678; vha100-4
Summary: Predicted to enable ATPase binding activity. Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport and vacuolar acidification. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Predicted to be active in plasma membrane. Is expressed in adult head; copper cell primordium; dorsal epidermis primordium; embryonic/larval midgut; and prothoracic gland. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; developmental and epileptic encephalopathy 104; renal tubular acidosis; and wrinkly skin syndrome. Orthologous to several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and ATP6V0A4 (ATPase H+ transporting V0 subunit a4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 91A5-91A5; 3-63 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18386841..18389805, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14212563..14215527, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G73114 (e-PCR)
- UniSTS:231393

MARC_7903-7904:996688149:1 (e-PCR)
- UniSTS:231393

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATPase activity, rotational mechanism	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in vacuolar acidification	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of vacuolar proton-transporting V-type ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: vacuolar H[+] ATPase 100kD subunit 4

Names: CG7678-PA; Vha100-4-PA; vacuolar H[+] ATPase subunit 100-4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

18386841..18389805 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_142463.3 → NP_650720.1 vacuolar H[+] ATPase 100kD subunit 4 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650720.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VE77

Related

FBpp0083073

Conserved Domains (2) summary

COG1269
Location:17 → 836

NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]

pfam01496
Location:40 → 834

V_ATPase_I; V-type ATPase 116kDa subunit family