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    Bhmt Betaine-homocysteine S-methyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35153, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bhmtprovided by FlyBase
    Official Full Name
    Betaine-homocysteine S-methyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032727
    Locus tag
    Dmel_CG10623
    See related
    AllianceGenome:FB:FBgn0032727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10623; dBHMT; Dmel\CG10623; Met-s
    Summary
    Predicted to enable S-adenosylmethionine-homocysteine S-methyltransferase activity; S-methylmethionine-homocysteine S-methyltransferase activity; and betaine-homocysteine S-methyltransferase activity. Predicted to be involved in S-methylmethionine cycle and methionine biosynthetic process. Is expressed in yolk nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Bhmt in Genome Data Viewer
    Location:
    37B7-37B7; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18955481..18957311, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18955481..18957311, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44741 Neighboring gene Numb-associated kinase Neighboring gene Transport and Golgi organization 6 Neighboring gene L-2-hydroxyglutarate dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic Targeting of dSAMTOR, A Negative dTORC1 Regulator, during Drosophila Aging: A Tissue-Specific Pathology. Katarachia SA, et al. Int J Mol Sci, 2023 Jun 2. PMID 37298625, Free PMC Article
    2. Recognition of age-damaged (R,S)-adenosyl-L-methionine by two methyltransferases in the yeast Saccharomyces cerevisiae. Vinci CR, et al. J Biol Chem, 2007 Mar 23. PMID 17264075
    3. The Transcriptional Corepressor SIN3 Directly Regulates Genes Involved in Methionine Catabolism and Affects Histone Methylation, Linking Epigenetics and Metabolism. Liu M, et al. J Biol Chem, 2017 Feb 3. PMID 28028175, Free PMC Article
    4. Sex-specific effects of cis-regulatory variants in Drosophila melanogaster. Coolon JD, et al. Genetics, 2013 Dec. PMID 24097411, Free PMC Article
    5. Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability. Liu M, et al. G3 (Bethesda), 2015 Nov 6. PMID 26546310, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables S-adenosylmethionine-homocysteine S-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-methylmethionine-homocysteine S-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables betaine-homocysteine S-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-methylmethionine cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Betaine-homocysteine S-methyltransferase
    Names
    Bhmt-PA
    Bhmt-PB
    Bhmt-PC
    CG10623-PA
    CG10623-PB
    CG10623-PC
    betaine-homocysteine methyl-transferase
    selenocysteine methyltransferase
    NP_001286073.1
    NP_001286074.1
    NP_609921.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18955481..18957311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299145.1 → NP_001286074.1  Betaine-homocysteine S-methyltransferase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286074.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0APQ1, A0APQ2, A0APR1, C0MKB3, C0MKB5, Q9VJ31
      Conserved Domains (1) summary
      cl22882
      Location:9 → 322
      S-methyl_trans; Homocysteine S-methyltransferase

    2. NM_136077.2 → NP_609921.1  Betaine-homocysteine S-methyltransferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609921.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0APQ1, A0APQ2, A0APR1, C0MKB3, C0MKB5, Q9VJ31
      Related
      FBpp0080731
      Conserved Domains (1) summary
      cl22882
      Location:9 → 322
      S-methyl_trans; Homocysteine S-methyltransferase

    3. NM_001299144.1 → NP_001286073.1  Betaine-homocysteine S-methyltransferase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286073.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0APQ1, A0APQ2, A0APR1, C0MKB3, C0MKB5, Q9VJ31
      Conserved Domains (1) summary
      cl22882
      Location:9 → 322
      S-methyl_trans; Homocysteine S-methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJ31 Q9VJ31

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