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    Cyp6a2 Cytochrome P450 6a2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35587, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Cyp6a2provided by FlyBase
    Official Full Name
    Cytochrome P450 6a2provided by FlyBase
    Primary source
    FLYBASE:FBgn0000473
    Locus tag
    Dmel_CG9438
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    143127_at; 6a2; 91-R; 91R; CG9438; Cyp6a; cyp6a2; Cyp6A2; CYP6a2; CYP6A2; Cyt-P450-B1; Dmel\CG9438; P-450; P-450-B; P450; P450-B; P450-B1
    Orthologs
    all
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    Genomic context

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    See Cyp6a2 in Genome Data Viewer
    Location:
    42D1-42D1; 2-55 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6779749..6781491, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2667254..2668996, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Eb1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Exchange protein directly activated by cAMP Neighboring gene uncharacterized protein Neighboring gene Succinate dehydrogenase, subunit B (iron-sulfur) Neighboring gene ubiquitin like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Point mutations associated with insecticide resistance in the Drosophila cytochrome P450 Cyp6a2 enable DDT metabolism. Amichot M, et al. Eur J Biochem, 2004 Apr. PMID 15030474
    2. Imidacloprid does not induce Cyp genes involved in insecticide resistance of a mutant Drosophila melanogaster line. Kalajdzic P, et al. Food Chem Toxicol, 2013 Oct. PMID 23933061
    3. Homology modelling of Drosophila cytochrome P450 enzymes associated with insecticide resistance. Jones RT, et al. Pest Manag Sci, 2010 Oct. PMID 20583201
    4. Nrf2/Maf-binding-site-containing functional Cyp6a2 allele is associated with DDT resistance in Drosophila melanogaster. Wan H, et al. Pest Manag Sci, 2014 Jul. PMID 24038867
    5. Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease. Islam MS, et al. Hum Mol Genet, 2016 Dec 15. PMID 27794539, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of functional Cyp6a2 was consistently associated with DDT resistance. Luciferase reporter gene assays revealed that an intact Nrf2/Maf binding site in the 5'-promoter core region enhanced the constitutive transcription of Cyp6a2.
      Title: Nrf2/Maf-binding-site-containing functional Cyp6a2 allele is associated with DDT resistance in Drosophila melanogaster.
    2. We find that Imidacloprid does not induce expression of the analyzed Cyp6g1 and Cyp6a2 genes.
      Title: Imidacloprid does not induce Cyp genes involved in insecticide resistance of a mutant Drosophila melanogaster line.
    3. The active site of CYP6G1 is significantly smaller than that of CYP6A2 or the CYP3A4.
      Title: Homology modelling of Drosophila cytochrome P450 enzymes associated with insecticide resistance.
    4. point mutations in cytochrome P450 Cyp6a2 can have a prominent role in insecticide resistance
      Title: Point mutations associated with insecticide resistance in the Drosophila cytochrome P450 Cyp6a2 enable DDT metabolism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    cytochrome P450 6a2
    Names
    CG9438-PA
    Cyp6a2-PA
    cytochrome P450
    cytochrome P450 B1
    cytochrome P450-6a2
    cytochrome P450-B1
    NP_523628.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6779749..6781491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078904.2 → NP_523628.1  cytochrome P450 6a2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523628.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P33270, P91669, Q5U1C1, Q9V9A2
      UniProtKB/TrEMBL
      A0A075BQY3, A0A075BR14
      Related
      FBpp0085466
      Conserved Domains (1) summary
      pfam00067
      Location:36 → 502
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33270.2 P33270

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