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    Ldh Lactate dehydrogenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45880, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Ldhprovided by FlyBase
    Official Full Name
    Lactate dehydrogenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001258
    Locus tag
    Dmel_CG10160
    See related
    AllianceGenome:FB:FBgn0001258
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10160; dLdh; dLDH; dLdha; Dmel\CG10160; dmLDH; Imp-L3; IMP-L3; Impl 3; impl3; impL3; Impl3; ImpL3; IMPL3; Ld; ldh; LDH; lincRNA.S4223
    Summary
    Enables L-lactate dehydrogenase activity and alpha-ketoglutarate reductase activity. Involved in NADH metabolic process; lactate catabolic process; and pyruvate metabolic process. Located in cytoplasm. Is expressed in several structures, including adult heart; imaginal disc; mesoderm; muscle cell; and organism subdivision. Used to study disease of metabolism. Orthologous to several human genes including LDHA (lactate dehydrogenase A); LDHAL6A (lactate dehydrogenase A like 6A); and LDHB (lactate dehydrogenase B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ldh in Genome Data Viewer
    Location:
    65A11-65A11; 3-16 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6259105..6262694, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6252205..6255794, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Bestrophin 2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44522 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanoresponsive regulation of myogenesis by the force-sensing transcriptional regulator Tono. Zhang X, et al. Curr Biol, 2024 Sep 23. PMID 39163855
    2. Lactate production is a prioritized feature of adipocyte metabolism. Krycer JR, et al. J Biol Chem, 2020 Jan 3. PMID 31690627, Free PMC Article
    3. Lactate dehydrogenase expression modulates longevity and neurodegeneration in Drosophila melanogaster. Long DM, et al. Aging (Albany NY), 2020 Jun 2. PMID 32484787, Free PMC Article
    4. Reclaiming Warburg: using developmental biology to gain insight into human metabolic diseases. Drummond-Barbosa D, et al. Development, 2020 Jun 14. PMID 32540896, Free PMC Article
    5. Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies. Frame AK, et al. Aging (Albany NY), 2023 Feb 28. PMID 36849157, Free PMC Article

    See all (216) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization of genetic and molecular tools for studying the endogenous expression of Lactate dehydrogenase in Drosophila melanogaster.
      Title: Characterization of genetic and molecular tools for studying the endogenous expression of Lactate dehydrogenase in Drosophila melanogaster.
    2. eIF4EHP promotes Ldh mRNA translation in and fruit fly adaptation to hypoxia.
      Title: eIF4EHP promotes Ldh mRNA translation in and fruit fly adaptation to hypoxia.
    3. Lactate dehydrogenase expression modulates longevity and neurodegeneration in Drosophila melanogaster.
      Title: Lactate dehydrogenase expression modulates longevity and neurodegeneration in Drosophila melanogaster.
    4. Drosophila melanogaster larvae lacking both LDH and G3P dehydrogenase (GPDH1) exhibit growth defects, synthetic lethality and decreased glycolytic flux.
      Title: Lactate dehydrogenase and glycerol-3-phosphate dehydrogenase cooperatively regulate growth and carbohydrate metabolism during Drosophila melanogaster larval development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-lactate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-lactate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-lactate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-ketoglutarate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NADH metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in NADH oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lactate biosynthetic process from pyruvate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lactate biosynthetic process from pyruvate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lactate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lactate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pyruvate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lactate dehydrogenase
    Names
    CG10160-PA
    CG10160-PB
    CG10160-PC
    CG10160-PD
    Ecdysone-induced gene L3
    Ecdysone-inducible gene L3
    Ldh-PA
    Ldh-PB
    Ldh-PC
    Ldh-PD
    lactate dehydrogenase B
    lactate/malate dehydrogenease
    lactic DH
    NP_001261474.1
    NP_001261475.1
    NP_001261476.1
    NP_476581.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6259105..6262694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274545.2 → NP_001261474.1  lactate dehydrogenase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261474.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95028, Q9VRW6
      UniProtKB/TrEMBL
      B5RJQ0, Q32KE6
      Conserved Domains (1) summary
      cd05293
      Location:18 → 329
      LDH_1; A subgroup of L-lactate dehydrogenases

    2. NM_057233.5 → NP_476581.1  lactate dehydrogenase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476581.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95028, Q9VRW6
      UniProtKB/TrEMBL
      B5RJQ0, Q32KE6
      Related
      FBpp0076716
      Conserved Domains (1) summary
      cd05293
      Location:18 → 329
      LDH_1; A subgroup of L-lactate dehydrogenases

    3. NM_001274547.1 → NP_001261476.1  lactate dehydrogenase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261476.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95028, Q9VRW6
      UniProtKB/TrEMBL
      B5RJQ0, Q32KE6
      Conserved Domains (1) summary
      cd05293
      Location:18 → 329
      LDH_1; A subgroup of L-lactate dehydrogenases

    4. NM_001274546.1 → NP_001261475.1  lactate dehydrogenase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261475.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95028, Q9VRW6
      UniProtKB/TrEMBL
      B5RJQ0, Q32KE6
      Conserved Domains (1) summary
      cd05293
      Location:18 → 329
      LDH_1; A subgroup of L-lactate dehydrogenases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5RJQ0 B5RJQ0
    Q95028.1 Q95028

    Gene LinkOut

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