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    Polr2I RNA polymerase II subunit I [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41741, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr2Iprovided by FlyBase
    Official Full Name
    RNA polymerase II subunit Iprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004855
    Locus tag
    Dmel_CG3284
    See related
    AllianceGenome:FB:FBgn0004855
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3284; Dmel\CG3284; dRPB9; H5; l(3)88Be; l(3)Z23; pol II; Pol II; polII; PolII; RNA pol II; RNA Pol II; RNA polII; RNAP; RNAP II; RNApolII; Rpb9; RPB9; RpII15; RPII15; RpII215
    Summary
    Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Involved in mitotic cell cycle. Located in nucleus. Part of RNA polymerase II, core complex. Is expressed in organism. Orthologous to human POLR2I (RNA polymerase II subunit I). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Polr2I in Genome Data Viewer
    Location:
    88B3-88B3; 3-55 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14309089..14310178)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10134811..10135900)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene red Malpighian tubules Neighboring gene Intraflagellar transport 54 Neighboring gene suppressor of Hairy wing Neighboring gene uncharacterized protein Neighboring gene Corazonin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RPII15 codes for the M(r) 15,000 subunit 9 of Drosophila melanogaster RNA polymerase II. Liu Z, et al. FEBS Lett, 1993 Nov 29. PMID 8243669
    2. RNA polymerase II subunits exhibit a broad distribution of macromolecular assembly states in the interchromatin space of cell nuclei. Tycon MA, et al. J Phys Chem B, 2014 Jan 16. PMID 24354435
    3. Determination of Coxiella burnetii rpoB sequence and its use for phylogenetic analysis. Mollet C, et al. Gene, 1998 Jan 19. PMID 9511749
    4. Kinetics of promoter Pol II on Hsp70 reveal stable pausing and key insights into its regulation. Buckley MS, et al. Genes Dev, 2014 Jan 1. PMID 24395245, Free PMC Article
    5. The suppressor of Hairy-wing protein regulates the tissue-specific expression of the Drosophila gypsy retrotransposon. Smith PA, et al. Genetics, 1995 Jan. PMID 7705625, Free PMC Article

    See all (119) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to DNA-directed 5'-3' RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle HMP PubMed 
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription-coupled nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase II, core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA polymerase II subunit I
    Names
    CG3284-PA
    CG3284-PB
    CG3284-PC
    Polr2I-PA
    Polr2I-PB
    Polr2I-PC
    RNA pol II
    RNA polymerase II
    RNA polymerase II 15kd subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14309089..14310178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300397.1 → NP_001287326.1  RNA polymerase II subunit I, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287326.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P36958, Q9VFK8
      UniProtKB/TrEMBL
      A0A0B4K652, B7FNR6
      Conserved Domains (2) summary
      COG1594
      Location:18 → 129
      RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
      cd10508
      Location:78 → 128
      Zn-ribbon_RPB9; C-terminal zinc ribbon domain of RPB9 subunit of RNA polymerase II

    2. NM_169575.3 → NP_731898.1  RNA polymerase II subunit I, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731898.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P36958, Q9VFK8
      UniProtKB/TrEMBL
      A0A0B4K652, B7FNR6
      Related
      FBpp0082384
      Conserved Domains (2) summary
      COG1594
      Location:18 → 129
      RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
      cd10508
      Location:78 → 128
      Zn-ribbon_RPB9; C-terminal zinc ribbon domain of RPB9 subunit of RNA polymerase II

    3. NM_001260170.2 → NP_001247099.1  RNA polymerase II subunit I, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247099.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P36958, Q9VFK8
      UniProtKB/TrEMBL
      A0A0B4K652, B7FNR6
      Conserved Domains (2) summary
      COG1594
      Location:18 → 129
      RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
      cd10508
      Location:78 → 128
      Zn-ribbon_RPB9; C-terminal zinc ribbon domain of RPB9 subunit of RNA polymerase II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K652 A0A0B4K652
    P36958.2 P36958

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