Sox15 Sox box protein 15 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sox15provided by FlyBase
Official Full Name: Sox box protein 15provided by FlyBase
Primary source: FLYBASE:FBgn0005613
Locus tag: Dmel_CG8404
See related: AllianceGenome:FB:FBgn0005613
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13945; CG8404; Dmel\CG8404; Dsox-15; DSox-15; Sox F; sox15; SOX15; Sox50E; SOX50E; SoxE; SoxF; SOXF
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including chaeta development; negative regulation of transcription by RNA polymerase II; and wing disc development. Located in nucleus. Is expressed in several structures, including antennal primordium; external sensory organ; imaginal disc; peripheral nervous system; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in hypotrichosis-lymphedema-telangiectasia syndrome; hypotrichosis-lymphedema-telangiectasia-renal defect syndrome; intracranial aneurysm; patent ductus arteriosus; and vesicoureteral reflux. Orthologous to several human genes including SOX18 (SRY-box transcription factor 18) and SOX7 (SRY-box transcription factor 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 50E4-50E4; 2-69 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14201390..14212413, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10088895..10099918, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We identify the conserved transcription factors Sox box protein 15 (Sox15) and Ftz transcription factor 1 (Ftz-f1) as genes controlled by dTcf/Pan involved in tumor development. In conclusion, this study reports a role for dTcf/Pan as a repressor of normal and oncogenic growth and identifies the genes inducing tumorigenesis downstream of dTcf/Pan.
Title: dTcf/Pangolin suppresses growth and tumor formation in Drosophila.
new feedback loop in the wg pathway in which the spatially restricted activation of the Sox gene SoxF (Sox15) by wg represses its own transcription, thus ensuring tight regulation of growth control
Title: SoxF is part of a novel negative-feedback loop in the wingless pathway that controls proliferation in the Drosophila wing disc.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0785 (e-PCR)
- UniSTS:32600

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaeta development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in wing disc development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Sox box protein 15

Names: CG8404-PA; Sox15-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

14201390..14212413 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079015.3 → NP_523739.2 Sox box protein 15 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523739.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P40657, Q1LZ22, Q4V734, Q9U1J5, Q9V6Y8

Related

FBpp0086702

Conserved Domains (1) summary

cd01388
Location:214 → 285

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...