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    beat-Ia beaten path Ia [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34947, updated on 9-Dec-2024

    Summary

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    Official Symbol
    beat-Iaprovided by FlyBase
    Official Full Name
    beaten path Iaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013433
    Locus tag
    Dmel_CG4846
    See related
    AllianceGenome:FB:FBgn0013433
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    beat; beat Ia; Beat Ia; beat-1a; Beat-Ia; beat1a; beat_1a; BG:DS00913.3; Cct; CCT; CG4846; CT15567; Dmel\CG4846; l(2)35Ea; l(2)35Eb; l(2)br47; l(2)br48; tric; TRiC
    Summary
    Involved in Bolwig's organ morphogenesis; axon development; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in extracellular region. Is expressed in motor neurons and presumptive embryonic/larval central nervous system. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See beat-Ia in Genome Data Viewer
    Location:
    35E2-35E2; 2-51 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16049965..16081684)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16049965..16081684)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44844 Neighboring gene beaten path Ic Neighboring gene uncharacterized protein Neighboring gene Bicaudal C Neighboring gene long non-coding RNA:CR44870 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Beat protein is related to adhesion proteins that contain immunoglobulin domains. Mushegian AR. Curr Biol, 1997 Jun 1. PMID 9197251
    2. Modular structure of the Drosophila Beat protein. Bazan JF, et al. Curr Biol, 1997 Jun 1. PMID 9197253
    3. Fasciclin II and Beaten path modulate intercellular adhesion in Drosophila larval visual organ development. Holmes AL, et al. Development, 1999 Jan. PMID 9847240
    4. Motoneuron differentiation, survival and synaptogenesis. deLapeyrière O, et al. Curr Opin Genet Dev, 1997 Oct. PMID 9388781
    5. The Drosophila beaten path gene encodes a novel secreted protein that regulates defasciculation at motor axon choice points. Fambrough D, et al. Cell, 1996 Dec 13. PMID 8978609

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Beat-Sidestep interaction network provides insights into Drosophila neuromuscular system development.
      Title: Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development.
    2. Controls adhesiveness levels in outgrowing embryonic motor axons during defasciculation. Mutants display a 'bypass' phenotype: growth cones fail to defasciculate from the pre-existing nerve and extend past their normal target muscles.
      Title: The Drosophila beaten path gene encodes a novel secreted protein that regulates defasciculation at motor axon choice points.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Bolwig's organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon choice point recognition TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defasciculation of motor neuron axon IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defasciculation of motor neuron axon IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beaten path Ia
    Names
    CG4846-PA
    CG4846-PB
    beat-Ia-PA
    beat-Ia-PB
    beaten path
    chaperonin containing TCP-1
    triclops

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16049965..16081684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299046.1 → NP_001285975.1  beaten path Ia, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285975.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J8L2
      Conserved Domains (1) summary
      cl11960
      Location:161 → 240
      Ig; Immunoglobulin domain

    2. NM_058160.4 → NP_477508.1  beaten path Ia, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477508.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q94534
      Related
      FBpp0080364
      Conserved Domains (1) summary
      cl11960
      Location:161 → 240
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BIA5 Q5BIA5
    Q94534 Q94534
    X2J8L2 X2J8L2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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