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    Pdi Protein disulfide isomerase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39651, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Pdiprovided by FlyBase
    Official Full Name
    Protein disulfide isomeraseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0286818
    Locus tag
    Dmel_CG6988
    See related
    AllianceGenome:FB:FBgn0286818
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6988; Dmel\CG6988; dpdi; Dpdi; EP(3)1022; l(3)j2A2; pdi; PDI
    Summary
    Predicted to enable protein disulfide isomerase activity. Predicted to be involved in protein folding and response to endoplasmic reticulum stress. Located in several cellular components, including fusome; rough endoplasmic reticulum; and spindle envelope. Is expressed in several structures, including adult brain cell body rind; adult head; epidermis; female germline cell; and germline cyst. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to several human genes including P4HB (prolyl 4-hydroxylase subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pdi in Genome Data Viewer
    Location:
    71B5-71B5; 3-42 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15137738..15142840, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15130838..15135940, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Centrosomal protein 135kDa Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : MeU5-U42 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45396 Neighboring gene antisense RNA:CR45397 Neighboring gene uncharacterized protein Neighboring gene Peroxin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila gene that encodes a member of the protein disulfide isomerase/phospholipase C-alpha family. McKay RR, et al. Insect Biochem Mol Biol, 1995 May. PMID 7787847
    2. Cloning of the alpha subunit of prolyl 4-hydroxylase from Drosophila and expression and characterization of the corresponding enzyme tetramer with some unique properties. Annunen P, et al. J Biol Chem, 1999 Mar 5. PMID 10037780
    3. Distribution of ryanodine receptor Ca(2+) channels in insect photoreceptor cells. Baumann O. J Comp Neurol, 2000 Jun 5. PMID 10813791
    4. The Drosophila reticulon, Rtnl-1, has multiple differentially expressed isoforms that are associated with a sub-compartment of the endoplasmic reticulum. Wakefield S, et al. Cell Mol Life Sci, 2006 Sep. PMID 16847576, Free PMC Article
    5. The twisted gene encodes Drosophila protein O-mannosyltransferase 2 and genetically interacts with the rotated abdomen gene encoding Drosophila protein O-mannosyltransferase 1. Lyalin D, et al. Genetics, 2006 Jan. PMID 16219785, Free PMC Article

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fusome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein disulfide isomerase
    Names
    CG6988-PA
    CG6988-PE
    Pdi-PA
    Pdi-PE
    disulfide isomerase
    lethal (3) j2A2
    proline diisomerease
    protein disulphide isomerase
    protein-disulfide isomerase
    NP_001287070.1
    NP_524079.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15137738..15142840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300141.1 → NP_001287070.1  protein disulfide isomerase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287070.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54399, Q53YH5, Q86PE2, Q8IQL8, Q9VUL7
      UniProtKB/TrEMBL
      X2JGP4
      Conserved Domains (5) summary
      cd02981
      Location:137 → 231
      PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02982
      Location:244 → 347
      PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02995
      Location:368 → 469
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      TIGR01126
      Location:33 → 133
      pdi_dom; protein disulfide-isomerase domain
      TIGR01130
      Location:27 → 474
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    2. NM_079355.3 → NP_524079.1  protein disulfide isomerase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524079.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54399, Q53YH5, Q86PE2, Q8IQL8, Q9VUL7
      UniProtKB/TrEMBL
      X2JGP4
      Related
      FBpp0075401
      Conserved Domains (5) summary
      cd02981
      Location:137 → 231
      PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02982
      Location:244 → 347
      PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02995
      Location:368 → 469
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      TIGR01126
      Location:33 → 133
      pdi_dom; protein disulfide-isomerase domain
      TIGR01130
      Location:27 → 474
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54399.1 P54399
    X2JGP4 X2JGP4

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