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    Ask1 Apoptotic signal-regulating kinase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42366, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ask1provided by FlyBase
    Official Full Name
    Apoptotic signal-regulating kinase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0014006
    Locus tag
    Dmel_CG4720
    See related
    AllianceGenome:FB:FBgn0014006
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Ask; ask1; ASK1; CG4720; D-ASK; dASK; DASK; dAsk1; dASK1; DASK1; Dmel\CG4720; DPk92B/ASK1; MEKK5/ASK1; pk92B; Pk92B
    Summary
    Enables MAP kinase kinase kinase activity. Involved in JNK cascade; positive regulation of JNK cascade; and regulation of adult chitin-containing cuticle pigmentation. Predicted to be part of protein kinase complex. Is expressed in adult brain. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to several human genes including MAP3K5 (mitogen-activated protein kinase kinase kinase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ask1 in Genome Data Viewer
    Location:
    92B4-92B4; 3-67 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19879719..19886030)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15705441..15711752)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Activator-recruited cofactor subunit 42 Neighboring gene neither inactivation nor afterpotential E Neighboring gene uncharacterized protein Neighboring gene Caseinolytic protease chaperone subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pk92B: a Drosophila melanogaster protein kinase that belongs to the MEKK family. Wassarman DA, et al. Gene, 1996 Mar 9. PMID 8647463
    2. Divergent signaling requirements of dSARM in injury-induced degeneration and developmental glial phagocytosis. Herrmann KA, et al. PLoS Genet, 2022 Jun. PMID 35737721, Free PMC Article
    3. Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila. Camilleri-Robles C, et al. Genes (Basel), 2019 May 18. PMID 31109086, Free PMC Article
    4. Distinct developmental and degenerative functions of SARM1 require NAD+ hydrolase activity. Brace EJ, et al. PLoS Genet, 2022 Jun. PMID 35737728, Free PMC Article
    5. PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila. Borch Jensen M, et al. Elife, 2017 Sep 11. PMID 28891792, Free PMC Article

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two upstream kinases, apoptotic signal-regulating kinase 1 (Ask1) and Licorne MAP kinase kinase 3 (MKK3), are required for p38 MAP kinase (p38) activation following infection, oxidative stress, detergent exposure and wounding.
      Title: Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut.
    2. Our findings demonstrate a non-autonomous activation of a ROS sensing mechanism by Ask1 and Akt1 to replace the missing tissue after damage. Collectively, these results provide the basis for understanding the molecular mechanism of communication between dying and living cells that triggers regeneration.
      Title: Ask1 and Akt act synergistically to promote ROS-dependent regeneration in Drosophila.
    3. Suggest that Slim/KLHDC10 is an activator of ASK1, contributing to oxidative stress-induced cell death through the suppression of PP5.
      Title: The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MAP kinase kinase kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of adult chitin-containing cuticle pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein kinase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    apoptotic signal-regulating kinase 1
    Names
    Ask1-PB
    Ask1-PC
    CG4720-PB
    CG4720-PC
    protein kinase at 92B
    NP_477089.3
    NP_996240.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19879719..19886030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206518.2 → NP_996240.1  apoptotic signal-regulating kinase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996240.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9EQQ2, Q7KSB7
      Conserved Domains (3) summary
      smart00220
      Location:423 → 676
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06624
      Location:409 → 676
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:1 → 277
      DUF4071; Domain of unknown function (DUF4071)

    2. NM_057741.4 → NP_477089.3  apoptotic signal-regulating kinase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477089.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9EQQ2, Q9VDS9
      Conserved Domains (3) summary
      smart00220
      Location:590 → 843
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06624
      Location:576 → 843
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:74 → 444
      DUF4071; Domain of unknown function (DUF4071)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24458 Q24458
    Q7KSB7 Q7KSB7
    Q8I6M5 Q8I6M5
    Q9VDS9 Q9VDS9

    Gene LinkOut

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