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    alpha-Est10 alpha-Esterase-10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40896, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alpha-Est10provided by FlyBase
    Official Full Name
    alpha-Esterase-10provided by FlyBase
    Primary source
    FLYBASE:FBgn0015569
    Locus tag
    Dmel_CG1131
    See related
    AllianceGenome:FB:FBgn0015569
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aE10; alpha-Ests; alphaE10; anon-WO0172774.144; CG1131; DmalphaE10; Dmel\CG1131; Esterase-10; K
    Summary
    Enables serine hydrolase activity. Is expressed in several structures, including adult head; embryonic/larval anterior midgut; embryonic/larval salivary gland; fat body; and nephrocyte. Orthologous to human CES3 (carboxylesterase 3) and CES4A (carboxylesterase 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alpha-Est10 in Genome Data Viewer
    Location:
    84D8-84D9; 3-48 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7486583..7493845, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3312305..3319567, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Valine-CAC 2-4 Neighboring gene small nuclear RNA 7SK a Neighboring gene alpha-Esterase-9 Neighboring gene uncharacterized protein Neighboring gene Mitochondrial morphology and cristae structure 1 Neighboring gene alpha-Esterase-8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of an alpha-esterase gene cluster on chromosome 3r of Drosophila melanogaster. Russell RJ, et al. Insect Biochem Mol Biol, 1996 Mar. PMID 8900595
    2. Developmental expression and gene/enzyme identifications in the alpha esterase gene cluster of Drosophila melanogaster. Campbell PM, et al. Insect Mol Biol, 2003 Oct. PMID 12974951
    3. Duplication and divergence of the genes of the alpha-esterase cluster of Drosophila melanogaster. Robin C, et al. J Mol Evol, 1996 Sep. PMID 8703090
    4. Reconstructing the diversification of alpha-esterases: comparing the gene clusters of Drosophila buzzatii and D. melanogaster. de Q Robin GC, et al. J Mol Evol, 2000 Aug. PMID 10948271
    5. Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster α-Esterase-7. Birner-Gruenberger R, et al. Insect Biochem Mol Biol, 2012 Mar. PMID 22198472

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxylesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    alpha-Esterase-10
    Names
    CG1131-PB
    CG1131-PC
    CG1131-PD
    Esterase-10
    alpha-Est10-PB
    alpha-Est10-PC
    alpha-Est10-PD
    fragment K
    NP_001246962.1
    NP_001246963.1
    NP_524257.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7486583..7493845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260033.2 → NP_001246962.1  alpha-Esterase-10, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246962.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6L1, Q24204
      Conserved Domains (2) summary
      COG0657
      Location:132 → 279
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:49 → 542
      COesterase; Carboxylesterase family

    2. NM_079533.4 → NP_524257.3  alpha-Esterase-10, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524257.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24204, Q9I7L5
      Conserved Domains (2) summary
      COG0657
      Location:118 → 265
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:35 → 528
      COesterase; Carboxylesterase family

    3. NM_001260034.1 → NP_001246963.1  alpha-Esterase-10, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246963.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K604, Q24204
      Conserved Domains (2) summary
      COG0657
      Location:101 → 248
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:18 → 511
      COesterase; Carboxylesterase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K604 A0A0B4K604
    A0A0B4K6L1 A0A0B4K6L1
    Q24204 Q24204
    Q9I7L5 Q9I7L5

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