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    Hmu Hemomucin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43294, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hmuprovided by FlyBase
    Official Full Name
    Hemomucinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015737
    Locus tag
    Dmel_CG3373
    See related
    AllianceGenome:FB:FBgn0015737
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3373; Dmel\CG3373; hmu; Rbp5; rrm5; RRM5; SPH210
    Summary
    Predicted to enable arylesterase activity. Predicted to be involved in biosynthetic process. Located in cell surface. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; ganglia; and gut section. Orthologous to human APMAP (adipocyte plasma membrane associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hmu in Genome Data Viewer
    Location:
    97F1-97F1; 3-93 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27288769..27291592)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23114491..23117314)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene martik Neighboring gene uncharacterized protein Neighboring gene bigmax Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44287 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Changes in glycosylation during Drosophila development. The influence of ecdysone on hemomucin isoforms. Theopold U, et al. Insect Biochem Mol Biol, 2001 Feb. PMID 11164341
    2. Is the surface of endoparasitic wasp eggs and larvae covered by a limited coagulation reaction? Kinuthia W, et al. J Insect Physiol, 1999 May. PMID 12770334
    3. Helix pomatia lectin, an inducer of Drosophila immune response, binds to hemomucin, a novel surface mucin. Theopold U, et al. J Biol Chem, 1996 May 31. PMID 8662683
    4. Animal and plant members of a gene family with similarity to alkaloid-synthesizing enzymes. Fabbri M, et al. Biochem Biophys Res Commun, 2000 Apr 29. PMID 10777701
    5. Peritrophic matrix proteins. Tellam RL, et al. Insect Biochem Mol Biol, 1999 Feb. PMID 10196732

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hmu, Sr-CI/Sr-CIII, and Tehao have polymorphic sites in nearly perfect linkage disequilibrium
      Title: Linkage disequilibrium and recent selection at three immunity receptor loci in Drosophila simulans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables arylesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables strictosidine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 

    General protein information

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    Preferred Names
    hemomucin
    Names
    CG3373-PA
    Hmu-PA
    RNA-binding protein 5
    NP_477159.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27288769..27291592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057811.4 → NP_477159.1  hemomucin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477159.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D2NUG9, Q24160, Q8MT56, Q9VB46
      UniProtKB/TrEMBL
      Q58SN2
      Related
      FBpp0084534
      Conserved Domains (2) summary
      COG3386
      Location:61 → 287
      YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
      cl22863
      Location:173 → 258
      Str_synth; Strictosidine synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q26275 Q26275
    Q58SM8 Q58SM8
    Q58SM9 Q58SM9
    Q58SN0 Q58SN0
    Q58SN1 Q58SN1
    Q58SN2 Q58SN2
    Q58SN3 Q58SN3
    Q58SN4 Q58SN4
    Q9VB46.1 Q9VB46

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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