psh persephone [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: pshprovided by FlyBase
Official Full Name: persephoneprovided by FlyBase
Primary source: FLYBASE:FBgn0030926
Locus tag: Dmel_CG6367
See related: AllianceGenome:FB:FBgn0030926
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: c-SP28; CG6367; cSP28; Dmel\CG6367; Psh; PSH; SP28
Summary: Enables serine-type endopeptidase activity. Involved in several processes, including Toll receptor ligand protein activation cascade; positive regulation of defense response; and response to bacterium. Located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 17B5-17B5; 1-60 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (18484487..18486921, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (18378520..18380954, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Persephone proteolytic cascade plays a crucial role in mediating DAMP-induced systemic responses in apoptosis-deficient Drosophila mutants
Title: Persephone/Spätzle pathogen sensors mediate the activation of Toll receptor signaling in response to endogenous danger signals in apoptosis-deficient Drosophila.
mutations in the persephone gene, which encodes a previously unknown serine protease, block induction of the Toll pathway by fungi and resistance to this type of infection
Title: Activation of Drosophila Toll during fungal infection by a blood serine protease.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables serine-type endopeptidase activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in Toll receptor ligand protein activation cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in Toll receptor ligand protein activation cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Toll receptor ligand protein activation cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antifungal innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to molecule of bacterial origin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antibacterial peptide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antifungal peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of melanization defense response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	ISM Inferred from Sequence Model more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: persephone

Names: CG6367-PA; psh-PA

NP_573297.1

EC 3.4.-.-

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

18484487..18486921 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_133069.2 → NP_573297.1 persephone [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_573297.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V9U0, A4V9U1, A4V9U4, A4V9U7, Q9VWU1

Related

FBpp0074400

Conserved Domains (3) summary

smart00680
Location:30 → 79

CLIP; Clip or disulphide knot domain

smart00020
Location:143 → 384

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:144 → 387

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...