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    CG17598 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33140, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17598provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031194
    Locus tag
    Dmel_CG17598
    See related
    AllianceGenome:FB:FBgn0031194
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG17598; PP2C
    Summary
    Predicted to enable [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity. Predicted to be involved in signal transduction. Predicted to be located in cytoplasm and nucleus. Predicted to be active in mitochondrion. Is expressed in organism. Orthologous to several human genes including PPM1J (protein phosphatase, Mg2+/Mn2+ dependent 1J). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17598 in Genome Data Viewer
    Location:
    20C1-20C1; 1-66 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (22534831..22540383, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21936667..21942219, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43493 Neighboring gene lethal (1) G0196 Neighboring gene long non-coding RNA:CR43962 Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein S6 kinase II Neighboring gene Clusterin associated protein 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The S6KII (rsk) gene of Drosophila melanogaster differentially affects an operant and a classical learning task. Putz G, et al. J Neurosci, 2004 Nov 3. PMID 15525759, Free PMC Article
    2. A phosphoswitch at acinus-serine(437) controls autophagic responses to cadmium exposure and neurodegenerative stress. Nandi N, et al. Elife, 2022 Jan 17. PMID 35037620, Free PMC Article
    3. Functional screening in Drosophila reveals the conserved role of REEP1 in promoting stress resistance and preventing the formation of Tau aggregates. Appocher C, et al. Hum Mol Genet, 2014 Dec 20. PMID 25096240
    4. Genome-wide RNAi screening implicates the E3 ubiquitin ligase Sherpa in mediating innate immune signaling by Toll in Drosophila adults. Kanoh H, et al. Sci Signal, 2015 Oct 27. PMID 26508789
    5. Expression of cardiac myosin-binding protein-C (cMyBP-C) in Drosophila as a model for the study of human cardiomyopathies. Vu Manh TP, et al. Hum Mol Genet, 2005 Jan 1. PMID 15525659

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17598-PA
    CG17598-PB
    NP_001259780.1
    NP_608468.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      22534831..22540383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272851.1 → NP_001259780.1  uncharacterized protein Dmel_CG17598, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259780.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T991, Q9VR62
      Conserved Domains (1) summary
      cd00143
      Location:98 → 506
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    2. NM_134624.4 → NP_608468.1  uncharacterized protein Dmel_CG17598, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608468.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T991, Q9VR62
      Related
      FBpp0077056
      Conserved Domains (1) summary
      cd00143
      Location:98 → 506
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VR62 Q9VR62

    Gene LinkOut

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