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    frtz fritz [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33349, updated on 9-Dec-2024

    Summary

    Official Symbol
    frtzprovided by FlyBase
    Official Full Name
    fritzprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086698
    Locus tag
    Dmel_CG17657
    See related
    AllianceGenome:FB:FBgn0086698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.105; CG17657; Dmel\CG17657; Frtz
    Summary
    Involved in imaginal disc-derived wing hair site selection. Predicted to be active in axonemal basal plate. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 15 and congenital heart defects, hamartomas of tongue, and polysyndactyly. Orthologous to human WDPCP (WD repeat containing planar cell polarity effector). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See frtz in Genome Data Viewer
    Location:
    22B1-22B1; 2-3 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1711302..1715851, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1711302..1715851, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene capping protein beta Neighboring gene antisense RNA:CR44976 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L48 Neighboring gene Replication in mitochondria 2 Neighboring gene Enolase Neighboring gene Ribosomal RNA processing 40

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    mobile_element

    • Loc: c1711678-1711411 mobile_element_type = transposon:mdg3{}290

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cilium organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in imaginal disc-derived wing hair site selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in axonemal basal plate IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    fritz
    Names
    CG17657-PA
    CG17657-PB
    CG17657-PD
    frtz-PA
    frtz-PB
    frtz-PD

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1711302..1715851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272951.1NP_001259880.1  fritz, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259880.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE00
      Conserved Domains (2) summary
      pfam11768
      Location:47596
      DUF3312; Protein of unknown function (DUF3312)
      cl02567
      Location:308384
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_134770.2NP_608614.1  fritz, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608614.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQ36
      UniProtKB/TrEMBL
      M9PBR4
      Related
      FBpp0077577
      Conserved Domains (2) summary
      pfam11768
      Location:47596
      DUF3312; Protein of unknown function (DUF3312)
      cl02567
      Location:308384
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001272950.1NP_001259879.1  fritz, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259879.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQ36
      UniProtKB/TrEMBL
      M9PBR4
      Conserved Domains (2) summary
      pfam11768
      Location:47596
      DUF3312; Protein of unknown function (DUF3312)
      cl02567
      Location:308384
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...