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    alpha4GT1 alpha1,4-galactosyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33512, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alpha4GT1provided by FlyBase
    Official Full Name
    alpha1,4-galactosyltransferase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031491
    Locus tag
    Dmel_CG17223
    See related
    AllianceGenome:FB:FBgn0031491
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha-4GT1; CG17223; Dmel\CG17223
    Summary
    Enables alpha-1,4-N-acetylgalactosaminyltransferase activity. Involved in glycosphingolipid biosynthetic process and negative regulation of apoptotic process. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic/larval midgut primordium; eye disc; ganglia; and nurse cell. Orthologous to human A4GALT (alpha 1,4-galactosyltransferase (P1PK blood group)) and A4GNT (alpha-1,4-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alpha4GT1 in Genome Data Viewer
    Location:
    23C4-23C4; 2-8 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3021309..3023141, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3021309..3023141, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ccdc85 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pre-mRNA processing factor 40 Neighboring gene Splicing factor 3b subunit 2 Neighboring gene antisense RNA:CR44147 Neighboring gene uncharacterized protein Neighboring gene beta4GalNAcTB pilot

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila melanogaster homologue of the human histo-blood group Pk gene encodes a glycolipid-modifying alpha1,4-N-acetylgalactosaminyltransferase. Mucha J, et al. Biochem J, 2004 Aug 15. PMID 15130086, Free PMC Article
    2. Drosophila alpha-1,4-glycosyltransferase (alpha-4GT1) inhibits reaper-mediated apoptosis in the eye. Protzer CE, et al. Cell Tissue Res, 2009 Apr. PMID 19252929
    3. Glycosphingolipids with extended sugar chain have specialized functions in development and behavior of Drosophila. Chen YW, et al. Dev Biol, 2007 Jun 15. PMID 17498683
    4. Notch ligand activity is modulated by glycosphingolipid membrane composition in Drosophila melanogaster. Hamel S, et al. J Cell Biol, 2010 Feb 22. PMID 20176925, Free PMC Article
    5. Roles of sphingolipids in Drosophila development and disease. Kraut R. J Neurochem, 2011 Mar. PMID 21214556

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The downregulation of alpha-4GT1 during eye development amplifies cell death induction by the pro-apoptotic gene reaper.
      Title: Drosophila alpha-1,4-glycosyltransferase (alpha-4GT1) inhibits reaper-mediated apoptosis in the eye.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetylgalactosaminyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables alpha-1,4-N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,4-N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycosphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycosphingolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycosphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha1,4-galactosyltransferase 1
    Names
    CG17223-PA
    alpha1,4-N-acetylgalactosaminyltransferase 1
    alpha1,4-N-acetylgalactosaminyltransferase-1
    alpha4GT1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3021309..3023141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134893.4 → NP_608737.1  alpha1,4-galactosyltransferase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608737.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6KCK5, Q9VQK4
      Related
      FBpp0077354
      Conserved Domains (2) summary
      pfam04488
      Location:99 → 217
      Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
      pfam04572
      Location:239 → 365
      Gb3_synth; Alpha 1,4-glycosyltransferase conserved region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6KCK5 Q6KCK5
    Q9VQK4 Q9VQK4

    Gene LinkOut

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