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    Art2 Arginine methyltransferase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33631, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Art2provided by FlyBase
    Official Full Name
    Arginine methyltransferase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0031592
    Locus tag
    Dmel_CG3675
    See related
    AllianceGenome:FB:FBgn0031592
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3675; Dart2; DART2; Dmel\CG3675
    Summary
    Predicted to enable histone methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; and protein-arginine omega-N monomethyltransferase activity. Predicted to be involved in chromatin remodeling and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in organism and ovary. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Art2 in Genome Data Viewer
    Location:
    24E1-24E1; 2-12 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4277696..4281324, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4277696..4281324, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44080 Neighboring gene uncharacterized protein Neighboring gene turtle Neighboring gene borderless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy. Scaramuzzino C, et al. Neuron, 2015 Jan 7. PMID 25569348, Free PMC Article
    2. A novel BLAST-Based Relative Distance (BBRD) method can effectively group members of protein arginine methyltransferases and suggest their evolutionary relationship. Wang YC, et al. Mol Phylogenet Evol, 2015 Mar. PMID 25576770
    3. Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4. Boulanger MC, et al. Biochem J, 2004 Apr 15. PMID 14705965, Free PMC Article
    4. Genomic variation in natural populations of Drosophila melanogaster. Langley CH, et al. Genetics, 2012 Oct. PMID 22673804, Free PMC Article
    5. Mining histone methyltransferases and demethylases from whole genome sequence. Gulati P, et al. J Biosci, 2020. PMID 31965987

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-arginine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-arginine omega-N asymmetric methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-arginine omega-N monomethyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-arginine omega-N monomethyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-arginine methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    arginine methyltransferase 2
    Names
    Art2-PA
    Art2-PB
    CG3675-PA
    CG3675-PB
    NP_001285600.1
    NP_608821.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4277696..4281324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298671.1 → NP_001285600.1  arginine methyltransferase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285600.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQX9
      Conserved Domains (1) summary
      cd02440
      Location:70 → 150
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_134977.2 → NP_608821.1  arginine methyltransferase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608821.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQX9
      Related
      FBpp0077165
      Conserved Domains (1) summary
      cd02440
      Location:70 → 150
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQX9 Q9VQX9

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