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    Mon1 Monensin sensitivity 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33689, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mon1provided by FlyBase
    Official Full Name
    Monensin sensitivity 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031640
    Locus tag
    Dmel_CG11926
    See related
    AllianceGenome:FB:FBgn0031640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11926; Dmel\CG11926; dMon1; Dmon1; mon1; MON1; NP_608868
    Summary
    Enables guanyl nucleotide exchange factor inhibitor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in endosome to lysosome transport via multivesicular body sorting pathway and neuromuscular junction development. Located in cytosol and synaptic cleft. Part of Mon1-Ccz1 complex. Is expressed in adult head. Orthologous to several human genes including MON1A (MON1 homolog A, secretory trafficking associated). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mon1 in Genome Data Viewer
    Location:
    25B1-25B1; 2-14 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4850641..4852640)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4850641..4852640)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene mextli Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S2 Neighboring gene smog Neighboring gene Chorion factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cryo-EM structure of the Mon1-Ccz1-RMC1 complex reveals molecular basis of metazoan RAB7A activation. Yong X, et al. Proc Natl Acad Sci U S A, 2023 May 30. PMID 37216550, Free PMC Article
    2. Drosophila Mon1 and Rab7 interact to regulate glutamate receptor levels at the neuromuscular junction. Basargekar A, et al. Int J Dev Biol, 2020. PMID 32658990
    3. Rab26 controls secretory granule maturation and breakdown in Drosophila. Boda A, et al. Cell Mol Life Sci, 2023 Jan 4. PMID 36600084, Free PMC Article
    4. A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function. Dehnen L, et al. J Cell Sci, 2020 Jul 9. PMID 32499409
    5. Monensin Sensitive 1 Regulates Dendritic Arborization in Drosophila by Modulating Endocytic Flux. Harish RK, et al. Front Cell Dev Biol, 2019. PMID 31428611, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila Mon1 and Rab7 interact to regulate glutamate receptor levels at the neuromuscular junction.
      Title: Drosophila Mon1 and Rab7 interact to regulate glutamate receptor levels at the neuromuscular junction.
    2. Mon1 is a novel molecular player in the brain-gonad axis; this underscores the significance of inter-organ systemic communication during development.
      Title: Drosophila Mon1 constitutes a novel node in the brain-gonad axis that is essential for female germline maturation.
    3. We propose that DMon1 is part of a presynaptically regulated transsynaptic mechanism that regulates GluRIIA levels at the larval neuromuscular junction.
      Title: A Presynaptic Regulatory System Acts Transsynaptically via Mon1 to Regulate Glutamate Receptor Levels in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl nucleotide exchange factor inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endosome to lysosome transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome to lysosome transport via multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Mon1-Ccz1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Mon1-Ccz1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of Mon1-Ccz1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic cleft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    monensin sensitivity 1
    Names
    CG11926-PA
    Mon1 ortholog
    Mon1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4850641..4852640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135024.2 → NP_608868.1  monensin sensitivity 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608868.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VR38
      UniProtKB/TrEMBL
      Q8MRZ0
      Related
      FBpp0077079
      Conserved Domains (1) summary
      pfam03164
      Location:115 → 527
      Mon1; Trafficking protein Mon1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRZ0 Q8MRZ0
    Q9VR38 Q9VR38
    Q9VR38.1

    Gene LinkOut

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