U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    IP3K1 Inositol 1,4,5-triphosphate kinase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34300, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    IP3K1provided by FlyBase
    Official Full Name
    Inositol 1,4,5-triphosphate kinase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0032147
    Locus tag
    Dmel_CG4026
    See related
    AllianceGenome:FB:FBgn0032147
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.189; CG4026; D-IP3K1; Dmel\CG4026; dmIP3Kalpha; dmIP[[3]]Kalpha; Ip3k1; IP3KI; IP[[3]]K-1; UY530
    Summary
    Predicted to enable inositol tetrakisphosphate kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. Involved in response to oxidative stress. Located in cytoplasm. Orthologous to human ITPKA (inositol-trisphosphate 3-kinase A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See IP3K1 in Genome Data Viewer
    Location:
    30C9-30D1; 2-36 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9782384..9788499)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9782384..9788499)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pickpocket 18 Neighboring gene uncharacterized protein Neighboring gene pickpocket 11 Neighboring gene pickpocket 16 Neighboring gene hairpin RNA:CR18854 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Inositol 1,4,5-triphosphate kinase1 gene affects olfactory reception in Drosophila melanogaster. Gomez-Diaz C, et al. Behav Genet, 2006 Mar. PMID 16463070
    2. Regulation of inositol 1,4,5-trisphosphate 3-kinases by calcium and localization in cells. Lloyd-Burton SM, et al. J Biol Chem, 2007 Mar 30. PMID 17284449
    3. The wavy Mutation Maps to the Inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) Gene of Drosophila and Interacts with IP3R to Affect Wing Development. Dean DM, et al. G3 (Bethesda), 2015 Nov 27. PMID 26613949, Free PMC Article
    4. Control of oxidative stress resistance by IP3 kinase in Drosophila melanogaster. Monnier V, et al. Free Radic Biol Med, 2002 Nov 1. PMID 12398933
    5. Modulation of oxidative stress resistance in Drosophila melanogaster by gene overexpression. Monnier V, et al. Genesis, 2002 Sep-Oct. PMID 12324953

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IP(3)K-1 modulates epithelial cell apoptosis without involvement of bcl-2-type proteins.
      Title: Cell-specific inositol 1,4,5 trisphosphate 3-kinase mediates epithelial cell apoptosis in response to oxidative stress in Drosophila.
    2. the major route of IP6 synthesis depends on the activities of dmIpk2 and dmIpk1, but not dmIP3K, offering a new role for IP3K in the genesis of higher IP messengers
      Title: A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-1,4,5-trisphosphate 3-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    inositol 1,4,5-triphosphate kinase 1
    Names
    CG4026-PA
    CG4026-PB
    IP3 kinase 1
    IP3K1-PA
    IP3K1-PB
    inositol 1,4,5-triphosphate kinase1
    NP_001245954.1
    NP_609313.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9782384..9788499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135469.4 → NP_609313.2  inositol 1,4,5-triphosphate kinase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609313.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95R55, Q9VL83
      Related
      FBpp0079465
      Conserved Domains (1) summary
      pfam03770
      Location:220 → 426
      IPK; Inositol polyphosphate kinase

    2. NM_001259025.1 → NP_001245954.1  inositol 1,4,5-triphosphate kinase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245954.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6W4K9, M9ND56
      Conserved Domains (1) summary
      pfam03770
      Location:97 → 303
      IPK; Inositol polyphosphate kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9ND56 M9ND56
    Q95R55 Q95R55
    Q9VL83 Q9VL83

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous