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    Vps13 Vacuolar protein sorting 13 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35693, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vps13provided by FlyBase
    Official Full Name
    Vacuolar protein sorting 13provided by FlyBase
    Primary source
    FLYBASE:FBgn0033194
    Locus tag
    Dmel_CG2093
    See related
    AllianceGenome:FB:FBgn0033194
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD02743; CG2093; Dmel\CG2093
    Summary
    Predicted to be involved in protein retention in Golgi apparatus and protein targeting to vacuole. Located in late endosome membrane. Is expressed in adult head and adult heart. Used to study choreaacanthocytosis. Human ortholog(s) of this gene implicated in Parkinson's disease 23; choreaacanthocytosis; and choreatic disease. Orthologous to several human genes including VPS13A (vacuolar protein sorting 13 homolog A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vps13 in Genome Data Viewer
    Location:
    43D7-43E1; 2-57 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7566809..7580675)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3454314..3468180)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene corin Neighboring gene Ribulose-5-phosphate-3-epimerase Neighboring gene boca Neighboring gene antisense RNA:CR45130 Neighboring gene blown fuse Neighboring gene uncharacterized protein Neighboring gene scraps

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast and other lower eukaryotic organisms for studies of Vps13 proteins in health and disease. Rzepnikowska W, et al. Traffic, 2017 Nov. PMID 28846184
    2. Drosophila Vps13 Is Required for Protein Homeostasis in the Brain. Vonk JJ, et al. PLoS One, 2017. PMID 28107480, Free PMC Article
    3. Vps13 is required for timely removal of nurse cell corpses. Faber AIE, et al. Development, 2020 Oct 29. PMID 32994170
    4. Parkinson's disease risk genes act in glia to control neuronal α-synuclein toxicity. Olsen AL, et al. Neurobiol Dis, 2021 Nov. PMID 34390834, Free PMC Article
    5. Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility. Yeshaw WM, et al. Elife, 2019 Feb 11. PMID 30741634, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in protein retention in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar protein sorting 13
    Names
    CG2093-PA
    CG2093-PB
    Vps13-PA
    Vps13-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7566809..7580675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273852.1 → NP_001260781.1  vacuolar protein sorting 13, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260781.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z713
      Conserved Domains (6) summary
      pfam06650
      Location:2349 → 2600
      SHR-BD; SHR-binding domain of vacuolar-sorting associated protein 13
      pfam12624
      Location:4 → 113
      Chorein_N; N-terminal region of Chorein or VPS13
      pfam16908
      Location:140 → 370
      VPS13; Vacuolar sorting-associated protein 13, N-terminal
      pfam16909
      Location:2904 → 3074
      VPS13_C; Vacuolar-sorting-associated 13 protein C-terminal
      pfam16910
      Location:574 → 807
      VPS13_mid_rpt; Repeating coiled region of VPS13
      cl25572
      Location:2701 → 3232
      VPS13; Vacuolar sorting-associated protein 13, N-terminal

    2. NM_136455.3 → NP_610299.2  vacuolar protein sorting 13, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610299.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z713
      Conserved Domains (6) summary
      pfam06650
      Location:2349 → 2600
      SHR-BD; SHR-binding domain of vacuolar-sorting associated protein 13
      pfam12624
      Location:4 → 113
      Chorein_N; N-terminal region of Chorein or VPS13
      pfam16908
      Location:140 → 370
      VPS13; Vacuolar sorting-associated protein 13, N-terminal
      pfam16909
      Location:2904 → 3074
      VPS13_C; Vacuolar-sorting-associated 13 protein C-terminal
      pfam16910
      Location:574 → 807
      VPS13_mid_rpt; Repeating coiled region of VPS13
      cl25572
      Location:2701 → 3232
      VPS13; Vacuolar sorting-associated protein 13, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z713.2 A1Z713

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