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    TTLL12 Tubulin tyrosine ligase-like 12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35732, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TTLL12provided by FlyBase
    Official Full Name
    Tubulin tyrosine ligase-like 12provided by FlyBase
    Primary source
    FLYBASE:FBgn0033225
    Locus tag
    Dmel_CG1550
    See related
    AllianceGenome:FB:FBgn0033225
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1550; DmCG1550; Dmel\CG1550
    Summary
    Predicted to enable protein-glycine ligase activity. Predicted to be involved in protein modification process. Predicted to be active in cytoplasm. Is expressed in embryonic/larval midgut and organism. Orthologous to human TTLL12 (tubulin tyrosine ligase like 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TTLL12 in Genome Data Viewer
    Location:
    43E18-43E18; 2-57 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7810068..7812028, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3697573..3699533, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene DNA polymerase zeta subunit 1 Neighboring gene Nop17 like Neighboring gene saxophone Neighboring gene pummelig Neighboring gene cathepsin D Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Janke C, et al. Science, 2005 Jun 17. PMID 15890843
    2. Testing Implications of the Omnigenic Model for the Genetic Analysis of Loci Identified through Genome-wide Association. Zhang W, et al. Curr Biol, 2021 Mar 8. PMID 33417882
    3. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article
    4. A Drosophila protein-interaction map centered on cell-cycle regulators. Stanyon CA, et al. Genome Biol, 2004. PMID 15575970, Free PMC Article
    5. Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. Blanco E, et al. BMC Dev Biol, 2010 Sep 2. PMID 20813047, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-glycine ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tubulin tyrosine ligase-like 12
    Names
    CG1550-PA
    TTLL12-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7810068..7812028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136481.3 → NP_610325.1  tubulin tyrosine ligase-like 12 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610325.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JVG6
      Related
      FBpp0087973
      Conserved Domains (1) summary
      cl17255
      Location:328 → 613
      ATP-grasp_4; ATP-grasp domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JVG6 Q7JVG6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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