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    uno univalents only [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35778, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unoprovided by FlyBase
    Official Full Name
    univalents onlyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033258
    Locus tag
    Dmel_CG8712
    See related
    AllianceGenome:FB:FBgn0033258
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8712; Dmel\CG8712
    Summary
    Enables chromatin binding activity. Involved in achiasmate meiosis I; homologous chromosome pairing at meiosis; and male meiosis I. Located in condensed chromosome; nucleolus; and nucleoplasm. Is expressed in embryonic brain; larval ventral nerve cord; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See uno in Genome Data Viewer
    Location:
    44A4-44A4; 2-58 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8096792..8098484, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3984297..3985989, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene sugar transporter 2 Neighboring gene sugar transporter 3 Neighboring gene sandman Neighboring gene Transmembrane protein 63 Neighboring gene Cullin 4 Neighboring gene under-developed

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Age-dependent diastolic heart failure in an in vivo Drosophila model. Klassen MP, et al. Elife, 2017 Mar 22. PMID 28328397, Free PMC Article
    2. Uncharted territories: Solving the mysteries of male meiosis in flies. Lee L, et al. PLoS Genet, 2024 Mar. PMID 38489251, Free PMC Article
    3. Homologous chromosomes are stably conjoined for Drosophila male meiosis I by SUM, a multimerized protein assembly with modules for DNA-binding and for separase-mediated dissociation co-opted from cohesin. Kabakci Z, et al. PLoS Genet, 2022 Dec. PMID 36480577, Free PMC Article
    4. Teflon promotes chromosomal recruitment of homolog conjunction proteins during Drosophila male meiosis. Kabakci Z, et al. PLoS Genet, 2022 Oct. PMID 36251690, Free PMC Article
    5. Bivalent individualization during chromosome territory formation in Drosophila spermatocytes by controlled condensin II protein activity and additional force generators. Vernizzi L, et al. PLoS Genet, 2021 Oct. PMID 34669718, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in achiasmate meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    univalents only
    Names
    CG8712-PA
    CG8712-PB
    uno-PA
    uno-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8096792..8098484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165587.2 → NP_724644.1  univalents only, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724644.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQU5
      Related
      FBpp0087899

    2. NM_136506.3 → NP_610350.2  univalents only, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610350.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQU5
      Related
      FBpp0087898
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JQU5 Q7JQU5

    Gene LinkOut

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