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    CG13748 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35896, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG13748provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033355
    Locus tag
    Dmel_CG13748
    See related
    AllianceGenome:FB:FBgn0033355
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG13748
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; leukemia (multiple); osteonecrosis; thrombophilia (multiple); and toxic shock syndrome. Orthologous to human TFPI (tissue factor pathway inhibitor) and TFPI2 (tissue factor pathway inhibitor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG13748 in Genome Data Viewer
    Location:
    44F9-44F9; 2-59 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8940415..8941136)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4827920..4828641)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Baramicin B Neighboring gene Fanconi anemia complementation group I Neighboring gene long non-coding RNA:CR44273 Neighboring gene long non-coding RNA:CR44274

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Proc Natl Acad Sci U S A, 2022 May 31. PMID 35617426, Free PMC Article
    2. Functional correlates of positional and gender-specific renal asymmetry in Drosophila. Chintapalli VR, et al. PLoS One, 2012. PMID 22496733, Free PMC Article
    3. Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association. Hamilton PT, et al. mBio, 2015 Sep 15. PMID 26374124, Free PMC Article
    4. Functional analysis of PGRP-LA in Drosophila immunity. Gendrin M, et al. PLoS One, 2013. PMID 23922788, Free PMC Article
    5. Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. Palu RA, et al. PLoS Genet, 2016 Apr. PMID 27058248, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG13748-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8940415..8941136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136586.2 → NP_610430.1  uncharacterized protein Dmel_CG13748 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610430.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7L2
      Related
      FBpp0087737
      Conserved Domains (1) summary
      pfam00014
      Location:59 → 110
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7L2 A1Z7L2

    Gene LinkOut

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