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    Urod Uroporphyrinogen decarboxylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35986, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Urodprovided by FlyBase
    Official Full Name
    Uroporphyrinogen decarboxylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033428
    Locus tag
    Dmel_CG1818
    See related
    AllianceGenome:FB:FBgn0033428
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1818; Dmel\CG1818; Updo
    Summary
    Predicted to enable uroporphyrinogen decarboxylase activity. Predicted to be involved in heme biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and embryonic/larval midgut primordium. Used to study porphyria. Human ortholog(s) of this gene implicated in porphyria cutanea tarda. Orthologous to human UROD (uroporphyrinogen decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Urod in Genome Data Viewer
    Location:
    45F5-45F5; 2-61 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9584643..9586126)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5472148..5473631)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Not1 Neighboring gene long non-coding RNA:CR46257 Neighboring gene 5' nucleotidase C Neighboring gene SET and MYND domain containing, class 4, member 1 Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L31 Neighboring gene closca Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glycogen branching enzyme controls cellular iron homeostasis via Iron Regulatory Protein 1 and mitoNEET. Huynh N, et al. Nat Commun, 2019 Nov 29. PMID 31784520, Free PMC Article
    2. Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster. Wang Z, et al. BMC Biol, 2022 Jun 2. PMID 35655259, Free PMC Article
    3. Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity. Ma S, et al. Aging Cell, 2018 Aug. PMID 29671950, Free PMC Article
    4. Evolution of amino-acid sequences and codon usage on the Drosophila miranda neo-sex chromosomes. Bartolomé C, et al. Genetics, 2006 Dec. PMID 17028318, Free PMC Article
    5. Rates and patterns of chromosomal evolution in Drosophila pseudoobscura and D. miranda. Bartolomé C, et al. Genetics, 2006 Jun. PMID 16547107, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables uroporphyrinogen decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uroporphyrinogen decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in porphyrin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uroporphyrinogen decarboxylase
    Names
    CG1818-PA
    Urod-PA
    updo
    NP_610501.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9584643..9586126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136657.3 → NP_610501.1  uroporphyrinogen decarboxylase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610501.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V595
      UniProtKB/TrEMBL
      B5RJ76, Q8MRV9
      Related
      FBpp0087607
      Conserved Domains (1) summary
      TIGR01464
      Location:14 → 354
      hemE; uroporphyrinogen decarboxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRV9 Q8MRV9
    Q9V595.1 Q9V595

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