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    luna luna [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768719, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lunaprovided by FlyBase
    Official Full Name
    lunaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040765
    Locus tag
    Dmel_CG33473
    See related
    AllianceGenome:FB:FBgn0040765
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17326; CG33473; CG9087; DKLF; Dmel\CG33473; Klf; KLF; lincRNA.284; Luna; LUNA
    Summary
    Enables sequence-specific DNA binding activity. Involved in mitotic sister chromatid segregation and preblastoderm mitotic cell cycle. Is expressed in embryonic anal pad; eye-antennal disc; and organism. Human ortholog(s) of this gene implicated in prostate cancer and stomach cancer. Orthologous to several human genes including KLF6 (KLF transcription factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See luna in Genome Data Viewer
    Location:
    47D1-47D4; 2-63 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10977956..11116378, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6865461..7003883, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45228 Neighboring gene Serpin 47C Neighboring gene long non-coding RNA:CR46409 Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 12d1 proximal Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Luna, a Drosophila KLF6/KLF7, is maternally required for synchronized nuclear and centrosome cycles in the preblastoderm embryo. Weber U, et al. PLoS One, 2014. PMID 24915236, Free PMC Article
    2. Identification of the Drosophila progenitor of mammalian Krüppel-like factors 6 and 7 and a determinant of fly development. De Graeve F, et al. Gene, 2003 Sep 18. PMID 14527717
    3. Modeling the Role of Wnt Signaling in Human and Drosophila Stem Cells. Kaur P, et al. Genes (Basel), 2018 Feb 16. PMID 29462894, Free PMC Article
    4. Simultaneous cellular and molecular phenotyping of embryonic mutants using single-cell regulatory trajectories. Secchia S, et al. Dev Cell, 2022 Feb 28. PMID 35176234, Free PMC Article
    5. Polycomb silencing of the Drosophila 4E-BP gene regulates imaginal disc cell growth. Mason-Suares H, et al. Dev Biol, 2013 Aug 1. PMID 23523430, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. luna mutants are associated with very early embryonic defects prior to cellularization at the syncytial stage and cause DNA separation defects.
      Title: Luna, a Drosophila KLF6/KLF7, is maternally required for synchronized nuclear and centrosome cycles in the preblastoderm embryo.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: c11018985-11009870 mobile_element_type = transposon:roo{}806
    • Loc: c11024938-11019954 mobile_element_type = transposon:jockey{}807

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in preblastoderm mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    luna
    Names
    CG33473-PB
    CG33473-PC
    CG33473-PD
    luna-PB
    luna-PC
    luna-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10977956..11116378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273950.1 → NP_001260879.1  luna, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260879.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MR37
      Conserved Domains (3) summary
      COG5048
      Location:455 → 559
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:489 → 511
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:533 → 558
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001299374.1 → NP_001286303.1  luna, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286303.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MR37
      Conserved Domains (3) summary
      COG5048
      Location:455 → 559
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:489 → 511
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:533 → 558
      zf-H2C2_2; Zinc-finger double domain

    3. NM_206089.2 → NP_995811.1  luna, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995811.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MR37
      Conserved Domains (3) summary
      COG5048
      Location:455 → 559
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:489 → 511
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:533 → 558
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MR37.1 Q8MR37

    Gene LinkOut

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