Syn2 Syntrophin-like 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Syn2provided by FlyBase
Official Full Name: Syntrophin-like 2provided by FlyBase
Primary source: FLYBASE:FBgn0034135
Locus tag: Dmel_CG4905
See related: AllianceGenome:FB:FBgn0034135
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4905; Dmel\CG4905; DmSYN-2
Summary: Predicted to be a structural constituent of muscle. Involved in locomotion; regulation of synaptic assembly at neuromuscular junction; and rhabdomere development. Predicted to be part of syntrophin complex. Is expressed in several structures, including central nervous system; dorsal pharyngeal muscle cell; embryonic/larval dorsal vessel; embryonic/larval posterior midgut; and head. Orthologous to several human genes including SNTG1 (syntrophin gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 53C7-53C7; 2-80 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16552258..16558486)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12439763..12445991)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Syn1 and Syn2 are required for locomotion and are involved in regulation of synaptic morphology
Title: Drosophila Syntrophins are involved in locomotion and regulation of synaptic morphology.
Syn2 is expressed throughout development, with especially high levels in the adult head. Syn2 knockdown resulted in lack of retinal elongation and malformation of rhabdomeres in adult flies, and excessive apoptosis in third instar larvae.
Title: Syntrophin-2 is required for eye development in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables structural constituent of muscle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in rhabdomere development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of dystrophin-associated glycoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of syntrophin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Syntrophin-like 2

Names: CG4905-PA; CG4905-PB; CG4905-PC; CG4905-PE; Syn2-PA; Syn2-PB; Syn2-PC; Syn2-PE; Syntrophin-2; syntrophin 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

16552258..16558486

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166179.4 → NP_725587.1 Syntrophin-like 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725587.1

Status: REVIEWED

UniProtKB/TrEMBL

E3CTN9, Q8SX22

Related

FBpp0086240

Conserved Domains (2) summary

smart00233
Location:296 → 402

PH; Pleckstrin homology domain

cd00992
Location:71 → 153

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_166180.4 → NP_725588.1 Syntrophin-like 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725588.1

Status: REVIEWED

UniProtKB/TrEMBL

E3CTN9, Q8SX22

Related

FBpp0086241

Conserved Domains (2) summary

smart00233
Location:296 → 402

PH; Pleckstrin homology domain

cd00992
Location:71 → 153

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_176201.3 → NP_788381.1 Syntrophin-like 2, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788381.1

Status: REVIEWED

UniProtKB/TrEMBL

A1ZAH3, E3CTN9

Related

FBpp0086244

Conserved Domains (2) summary

smart00233
Location:301 → 407

PH; Pleckstrin homology domain

cd00992
Location:76 → 158

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_079038.5 → NP_523762.2 Syntrophin-like 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523762.2

Status: REVIEWED

UniProtKB/TrEMBL

Q0E952, Q9GT68

Related

FBpp0086242

Conserved Domains (2) summary

smart00233
Location:241 → 347

PH; Pleckstrin homology domain

cd00992
Location:71 → 153

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...