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    Dlish Dachs ligand with SH3s [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37014, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dlishprovided by FlyBase
    Official Full Name
    Dachs ligand with SH3sprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034264
    Locus tag
    Dmel_CG10933
    See related
    AllianceGenome:FB:FBgn0034264
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10933; dlish; Dmel\CG10933; vam; Vam
    Summary
    Enables cadherin binding activity. Involved in several processes, including establishment of epithelial cell planar polarity; negative regulation of hippo signaling; and protein localization involved in establishment of planar polarity. Located in apical cortex; apicolateral plasma membrane; and subapical part of cell. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dlish in Genome Data Viewer
    Location:
    54E2-54E2; 2-84 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17723309..17725056)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13610814..13612561)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene U snoRNA host gene 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sorting nexin 16 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene hyccin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamics and stage-specificity of between-population gene expression divergence in the Drosophila melanogaster larval fat body. Glaser-Schmitt A, et al. PLoS Genet, 2023 Apr. PMID 37099612, Free PMC Article
    2. Expanded directly binds conserved regions of Fat to restrain growth via the Hippo pathway. Fulford AD, et al. J Cell Biol, 2023 May 1. PMID 37071483, Free PMC Article
    3. Emerging Mechanisms of Growth and Patterning Regulation by Dachsous and Fat Protocadherins. Gridnev A, et al. Front Cell Dev Biol, 2022. PMID 35372364, Free PMC Article
    4. Early girl is a novel component of the Fat signaling pathway. Misra JR, et al. PLoS Genet, 2019 Jan. PMID 30699121, Free PMC Article
    5. Fat-regulated adaptor protein Dlish binds the growth suppressor Expanded and controls its stability and ubiquitination. Wang X, et al. Proc Natl Acad Sci U S A, 2019 Jan 22. PMID 30606799, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cadherin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment of epithelial cell planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization involved in establishment of planar polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization involved in establishment of planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in subapical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dachs ligand with SH3s
    Names
    CG10933-PA
    Dlish-PA
    vamana

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17723309..17725056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137407.3 → NP_611251.2  dachs ligand with SH3s [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611251.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZAY1
      UniProtKB/TrEMBL
      Q8IGN9
      Related
      FBpp0086020
      Conserved Domains (2) summary
      cd00174
      Location:61 → 111
      SH3; Src Homology 3 domain superfamily
      smart00326
      Location:184 → 238
      SH3; Src homology 3 domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAY1.1 A1ZAY1
    Q8IGN9 Q8IGN9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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