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    Hil Hillarin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37328, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hilprovided by FlyBase
    Official Full Name
    Hillarinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050147
    Locus tag
    Dmel_CG30147
    See related
    AllianceGenome:FB:FBgn0050147
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10439; CG13435; CG30147; D-hil; Dmel\CG30147
    Summary
    Located in cell cortex and cleavage furrow. Is expressed in adult head. Human ortholog(s) of this gene implicated in myofibrillar myopathy 7. Orthologous to human KY (kyphoscoliosis peptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hil in Genome Data Viewer
    Location:
    57A7-57A7; 2-91 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20606881..20618217, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16494386..16505722, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Nnf1a Neighboring gene Heterogeneous nuclear ribonucleoprotein K Neighboring gene mir-7 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Family with sequence similarity 21 Neighboring gene Reduction in Cnn dots 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. D-Hillarin, a novel W180-domain protein, affects cytokinesis through interaction with the septin family member Pnut. Ji Y, et al. J Neurobiol, 2005 Aug. PMID 15818553
    2. A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye. Li X, et al. Cell, 2005 Dec 29. PMID 16377567
    3. A circular RNA-gawky-chromatin regulatory axis modulates stress-induced transcription. Su R, et al. Nucleic Acids Res, 2024 Apr 24. PMID 38416578, Free PMC Article
    4. The Roles of the LIM Domain Proteins in Drosophila Cardiac and Hematopoietic Morphogenesis. She M, et al. Front Cardiovasc Med, 2021. PMID 33681304, Free PMC Article
    5. Genome-wide identification of Grainy head targets in Drosophila reveals regulatory interactions with the POU domain transcription factor Vvl. Yao L, et al. Development, 2017 Sep 1. PMID 28760809, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The D-hil may function as a regulator of septin function during cytokinesis in the developing nervous system.
      Title: D-Hillarin, a novel W180-domain protein, affects cytokinesis through interaction with the septin family member Pnut.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hillarin
    Names
    CG30147-PA
    CG30147-PB
    D-hillarin
    Hil-PA
    Hil-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20606881..20618217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137649.3 → NP_611493.2  hillarin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611493.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E908, Q960G2
      Related
      FBpp0085568
      Conserved Domains (3) summary
      cd09443
      Location:11 → 70
      LIM_Ltd-1; The LIM domain of LIM and transglutaminase domains protein (Ltd-1)
      smart00460
      Location:418 → 486
      TGc; Transglutaminase/protease-like homologues
      cl12013
      Location:147 → 265
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_166402.2 → NP_725980.1  hillarin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725980.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E908, Q960G2
      Related
      FBpp0085567
      Conserved Domains (3) summary
      cd09443
      Location:11 → 70
      LIM_Ltd-1; The LIM domain of LIM and transglutaminase domains protein (Ltd-1)
      smart00460
      Location:418 → 486
      TGc; Transglutaminase/protease-like homologues
      cl12013
      Location:147 → 265
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E908.1 Q0E908

    Gene LinkOut

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