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    eEF5 eukaryotic translation elongation factor 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37846, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eEF5provided by FlyBase
    Official Full Name
    eukaryotic translation elongation factor 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0285952
    Locus tag
    Dmel_CG3186
    See related
    AllianceGenome:FB:FBgn0285952
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1296; anon-EST:fe2H10; CG3186; chr2R:19566878..19566998; Dmel\CG3186; eIF-5A; eIF5a; eIF5A; l(2)01296; l(2)SH2 2271; l(2)SH2271
    Summary
    Enables translation elongation factor activity. Involved in cytoplasmic translation and sexual reproduction. Predicted to be located in cytoplasm. Is expressed in adult head; adult heart; and organism. Orthologous to several human genes including EIF5AL1 (eukaryotic translation initiation factor 5A like 1) and EIF5A2 (eukaryotic translation initiation factor 5A2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eEF5 in Genome Data Viewer
    Location:
    60B7-60B7; 2-106 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24057798..24059483)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19945321..19947006)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene gamma Soluble NSF attachment protein 1 Neighboring gene seizure Neighboring gene pickpocket 29 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44814 Neighboring gene Ribosomal protein L12 Neighboring gene Ribosomal protein L39 Neighboring gene Ras-associated protein 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Changes in global translation elongation or initiation rates shape the proteome via the Kozak sequence. Acevedo JM, et al. Sci Rep, 2018 Mar 5. PMID 29507361, Free PMC Article
    2. Evolutionary conserved role of eukaryotic translation factor eIF5A in the regulation of actin-nucleating formins. Muñoz-Soriano V, et al. Sci Rep, 2017 Aug 29. PMID 28852021, Free PMC Article
    3. eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction. Liang Y, et al. Cell Rep, 2021 Apr 13. PMID 33852845
    4. Hypoxia Tolerant Species: The Wisdom of Nature Translated into Targets for Stroke Therapy. Del Río C, et al. Int J Mol Sci, 2021 Oct 15. PMID 34681788, Free PMC Article
    5. The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy. Patel PH, et al. J Cell Biol, 2009 Jun 29. PMID 19546244, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction.
      Title: eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction.
    2. Results describe the identification and characterization of nero, the Drosophila melanogaster deoxyhypusine hydroxylase (DOHH) homologue, and indicate that nero and eIF5A are required for cell growth and affect autophagy and protein synthesis.
      Title: The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables translation elongation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translational elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of translational termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation elongation factor 5
    Names
    CG3186-PA
    CG3186-PB
    anon-fast-evolving-2H10
    eEF5-PA
    eEF5-PB
    eIF-5A
    eukaryotic initiation factor 5A
    eukaryotic translation factor 5A
    lethal (2) SH2271

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24057798..24059483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166654.2 → NP_726411.1  eukaryotic translation elongation factor 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726411.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1B2AK02, Q2MGM4, Q9GU68, Q9NDH0, Q9W1C0
      Related
      FBpp0072081
      Conserved Domains (2) summary
      PLN03107
      Location:1 → 152
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
      pfam01287
      Location:84 → 152
      eIF-5a; Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold

    2. NM_138034.3 → NP_611878.1  eukaryotic translation elongation factor 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611878.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1B2AK02, Q2MGM4, Q9GU68, Q9NDH0, Q9W1C0
      Related
      FBpp0072082
      Conserved Domains (2) summary
      PLN03107
      Location:1 → 152
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
      pfam01287
      Location:84 → 152
      eIF-5a; Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GU68.2 Q9GU68

    Gene LinkOut

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