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    Ptip PAX transcription activation domain interacting protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39552, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptipprovided by FlyBase
    Official Full Name
    PAX transcription activation domain interacting proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052133
    Locus tag
    Dmel_CG32133
    See related
    AllianceGenome:FB:FBgn0052133
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32133; CG6532; CG8797; Dmel\CG32133; ptip; PTIP
    Summary
    Involved in anterior/posterior pattern specification, imaginal disc; embryonic pattern specification; and positive regulation of antibacterial peptide biosynthetic process. Part of MLL3/4 complex. Is expressed in several structures, including gland; gut section; imaginal disc; larval central nervous system; and larval ventral nerve cord. Orthologous to human PAXIP1 (PAX interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ptip in Genome Data Viewer
    Location:
    70C12-70C14; 3-41 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14020315..14029121, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14013415..14022221, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Nitrogen permease regulator-like 3 Neighboring gene upSET Neighboring gene endosulfine Neighboring gene antisense RNA:CR42871 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance. Dong YL, et al. Commun Biol, 2021 Mar 19. PMID 33742110, Free PMC Article
    2. Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Herz HM, et al. Genes Dev, 2012 Dec 1. PMID 23166019, Free PMC Article
    3. Genome-wide analysis of bivalent histone modifications during Drosophila embryogenesis. Cheng Q, et al. Genesis, 2022 Dec. PMID 36125264
    4. An essential role for PTIP in mediating Hox gene regulation along PcG and trxG pathways. Cheng Q, et al. FEBS J, 2022 Oct. PMID 35655387
    5. The COMPASS family of H3K4 methylases in Drosophila. Mohan M, et al. Mol Cell Biol, 2011 Nov. PMID 21875999, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification, imaginal disc IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antibacterial peptide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL3/4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MLL3/4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PAX transcription activation domain interacting protein
    Names
    CG32133-PA
    PAX transcription activation domain-interacting protein
    Ptip-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14020315..14029121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168571.3 → NP_729947.2  PAX transcription activation domain interacting protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729947.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUB7
      Related
      FBpp0075526
      Conserved Domains (4) summary
      smart00292
      Location:9 → 77
      BRCT; breast cancer carboxy-terminal domain
      cd00027
      Location:1814 → 1887
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam00533
      Location:96 → 174
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:1914 → 1976
      PTCB-BRCT; twin BRCT domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUB7 Q9VUB7

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