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    Adgf-A Adenosine deaminase-related growth factor A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39976, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adgf-Aprovided by FlyBase
    Official Full Name
    Adenosine deaminase-related growth factor Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036752
    Locus tag
    Dmel_CG5992
    See related
    AllianceGenome:FB:FBgn0036752
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ADGDF-A; ADGF; adgf-a; Adgf-a; ADGF-A; adgfa; AdgfA; CG5992; Dmel\CG5992
    Summary
    Enables adenosine deaminase activity. Involved in several processes, including adenosine catabolic process; cellular response to sucrose starvation; and larval lymph gland hemopoiesis. Located in extracellular space. Is expressed in several structures, including adult head; adult heart; endoderm anlage; head epidermis primordium; and larval muscle cell. Human ortholog(s) of this gene implicated in Sneddon syndrome. Orthologous to human ADA2 (adenosine deaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Adgf-A in Genome Data Viewer
    Location:
    75A1-75A1; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17751731..17764158, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17744831..17757258, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ccn Neighboring gene uncharacterized protein Neighboring gene Adenosine deaminase-related growth factor B Neighboring gene Adenosine deaminase-related growth factor A2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44668 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic dissection of innate immune memory in Drosophila melanogaster. Tang C, et al. Front Immunol, 2022. PMID 35990631, Free PMC Article
    2. The emerging role of adenosine deaminases in insects. Dolezelova E, et al. Insect Biochem Mol Biol, 2005 May. PMID 15804573
    3. Oxygenation and adenosine deaminase support growth and proliferation of ex vivo cultured Drosophila wing imaginal discs. Strassburger K, et al. Development, 2017 Jul 1. PMID 28526754
    4. Extracellular adenosine modulates host-pathogen interactions through regulation of systemic metabolism during immune response in Drosophila. Bajgar A, et al. PLoS Pathog, 2018 Apr. PMID 29702691, Free PMC Article
    5. The TEAD family transcription factor Scalloped regulates blood progenitor maintenance and proliferation in Drosophila through PDGF/VEGFR receptor (Pvr) signaling. Ferguson GB, et al. Dev Biol, 2017 May 1. PMID 28322737

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNAi screen identified Adenosine Receptor (AdoR) as a top candidate required for intestinal stem cell (ISC) self-renewal and proliferation in the Drosophila midgut. Down-regulation of adenosine deaminase-related growth factor A (Adgf-A) from enterocytes is necessary for extracellular adenosine to activate AdoR and induce ISC overproliferation and Adgf-A activity decreases following tissue damage.
      Title: An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity.
    2. Low ADGF-A expression is associated with increase in resistance to S. pneumoniae
      Title: Extracellular adenosine modulates host-pathogen interactions through regulation of systemic metabolism during immune response in Drosophila.
    3. The effects of increased adenosine in vivo by mutating the main Drosophila adenosine deaminase-related growth factor (ADGF-A), was studied.
      Title: Increased extracellular adenosine in Drosophila that are deficient in adenosine deaminase activates a release of energy stores leading to wasting and death.
    4. findings show that a null mutation in ADGF-A leads to dramatically increased levels of adenosine & deoxyadenosine in the larval hemolymph; this increase leads to larval death associated with the disintegration of fat body & development of melanotic tumors
      Title: A role for adenosine deaminase in Drosophila larval development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenosine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenosine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenosine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenosine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to sucrose starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hemocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in larval lymph gland hemopoiesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of carbohydrate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenosine deaminase-related growth factor A
    Names
    Adgf-A-PA
    Adgf-A-PB
    Ado deaminase growth factor-A
    CG5992-PA
    CG5992-PB
    adenosine deaminase
    adenosine deaminase growth Factor-A
    NP_524130.1
    NP_996119.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17751731..17764158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206397.2 → NP_996119.1  adenosine deaminase-related growth factor A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996119.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVK5
      Conserved Domains (3) summary
      cd01321
      Location:119 → 531
      ADGF; Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
      TIGR01431
      Location:66 → 538
      adm_rel; adenosine deaminase-related growth factor
      pfam08451
      Location:54 → 139
      A_deaminase_N; Adenosine/AMP deaminase N-terminal

    2. NM_079406.3 → NP_524130.1  adenosine deaminase-related growth factor A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524130.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVK5
      Related
      FBpp0074955
      Conserved Domains (3) summary
      cd01321
      Location:119 → 531
      ADGF; Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
      TIGR01431
      Location:66 → 538
      adm_rel; adenosine deaminase-related growth factor
      pfam08451
      Location:54 → 139
      A_deaminase_N; Adenosine/AMP deaminase N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVK5 Q9VVK5

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