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    CG33969 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40252, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG33969provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053969
    Locus tag
    Dmel_CG33969
    See related
    AllianceGenome:FB:FBgn0053969
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32429; CG5571; Dmel\CG33969
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in organism. Orthologous to human FBXW4 (F-box and WD repeat domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG33969 in Genome Data Viewer
    Location:
    77C1-77C1; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20391685..20393553, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20384785..20386653, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fumble Neighboring gene antisense RNA:CR43944 Neighboring gene long non-coding RNA:CR45677 Neighboring gene tribbles

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The kinase domain of Drosophila Tribbles is required for turnover of fly C/EBP during cell migration. Masoner V, et al. Dev Biol, 2013 Mar 1. PMID 23305818
    2. Many P-element insertions affect wing shape in Drosophila melanogaster. Weber K, et al. Genetics, 2005 Mar. PMID 15545659, Free PMC Article
    3. Prediction and verification of microRNA targets by MovingTargets, a highly adaptable prediction method. Burgler C, et al. BMC Genomics, 2005 Jun 8. PMID 15943864, Free PMC Article
    4. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article
    5. Mobile-phone radiation-induced perturbation of gene-expression profiling, redox equilibrium and sporadic-apoptosis control in the ovary of Drosophila melanogaster. Manta AK, et al. Fly (Austin), 2017 Apr 3. PMID 27960592, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG33969-PA
    CG33969-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20391685..20393553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038946.3 → NP_001034035.2  uncharacterized protein Dmel_CG33969, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034035.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V264
      Conserved Domains (2) summary
      COG2319
      Location:143 → 342
      WD40; WD40 repeat [General function prediction only]
      cl02567
      Location:180 → 388
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001038945.2 → NP_001034034.1  uncharacterized protein Dmel_CG33969, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034034.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX44, Q9VPG3
      Conserved Domains (2) summary
      COG2319
      Location:146 → 345
      WD40; WD40 repeat [General function prediction only]
      cl02567
      Location:183 → 391
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V264 A4V264
    Q8SX44 Q8SX44
    Q95S02 Q95S02

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