U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CtIP CTBP-interacting protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40262, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CtIPprovided by FlyBase
    Official Full Name
    CTBP-interacting proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036991
    Locus tag
    Dmel_CG5872
    See related
    AllianceGenome:FB:FBgn0036991
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5872; CTIP; dCtIP; Dmel\CG5872
    Summary
    Involved in DNA double-strand break processing involved in repair via single-strand annealing and double-strand break repair via homologous recombination. Is expressed in several structures, including Malpighian tubule primordium; central brain primordium; embryonic hindgut; foregut primordium; and ganglia. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CtIP in Genome Data Viewer
    Location:
    77C3-77C3; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20436250..20438370)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20429350..20431470)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Lipoic acid synthase Neighboring gene Presenilin Neighboring gene mitochondrial ribosomal protein L15 Neighboring gene long non-coding RNA:CR45176 Neighboring gene 4-hydroxyphenylpyruvate dioxygenase Neighboring gene long non-coding RNA:CR43943

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Role of Drosophila CtIP in Homology-Directed Repair of DNA Double-Strand Breaks. Yannuzzi I, et al. Genes (Basel), 2021 Sep 16. PMID 34573412, Free PMC Article
    2. The epistatic relationship of Drosophila melanogaster CtIP and Rif1 in homology-directed repair of DNA double-strand breaks. Thomas MS, et al. G3 (Bethesda), 2024 Nov 6. PMID 39397376, Free PMC Article
    3. Aging impairs double-strand break repair by homologous recombination in Drosophila germ cells. Delabaere L, et al. Aging Cell, 2017 Apr. PMID 28000382, Free PMC Article
    4. DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens. Mota MBS, et al. Parasit Vectors, 2019 Nov 11. PMID 31711518, Free PMC Article
    5. Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks. Merk K, et al. PLoS Genet, 2017 Jun. PMID 28628606, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The epistatic relationship of Drosophila melanogaster CtIP and Rif1 in homology-directed repair of DNA double-strand breaks.
      Title: The epistatic relationship of Drosophila melanogaster CtIP and Rif1 in homology-directed repair of DNA double-strand breaks.
    2. The Role of Drosophila CtIP in Homology-Directed Repair of DNA Double-Strand Breaks.
      Title: The Role of Drosophila CtIP in Homology-Directed Repair of DNA Double-Strand Breaks.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in DNA double-strand break processing involved in repair via single-strand annealing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    CTBP-interacting protein
    Names
    CG5872-PA
    CG5872-PB
    CtIP-PA
    CtIP-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20436250..20438370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300200.1 → NP_001287129.1  CTBP-interacting protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287129.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JBC3

    2. NM_140967.3 → NP_649224.1  CTBP-interacting protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649224.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYS4, Q9VPF5
      Related
      FBpp0077852
      Conserved Domains (1) summary
      pfam08573
      Location:362 → 471
      SAE2; DNA repair protein endonuclease SAE2/CtIP C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPF5 Q9VPF5
    X2JBC3 X2JBC3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools