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    Mkrn1 Makorin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44131, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mkrn1provided by FlyBase
    Official Full Name
    Makorin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0029152
    Locus tag
    Dmel_CG7184
    See related
    AllianceGenome:FB:FBgn0029152
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7184; Dmel\CG7184; mkrn1; MKRN1
    Summary
    Enables mRNA 3'-UTR binding activity. Involved in several processes, including positive regulation of insulin receptor signaling pathway; positive regulation of oogenesis; and positive regulation of oskar mRNA translation. Part of ribonucleoprotein complex. Is active in P granule. Is expressed in organism. Human ortholog(s) of this gene implicated in central precocious puberty 2. Orthologous to several human genes including MKRN1 (makorin ring finger protein 1) and MKRN4P (makorin ring finger protein 4, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mkrn1 in Genome Data Viewer
    Location:
    78D5-78D5; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21529959..21533713, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21523059..21526813, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43877 Neighboring gene ACAT-related protein required for viability 1 Neighboring gene pickpocket 5 Neighboring gene Regulatory particle non-ATPase 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system. Gray TA, et al. Genomics, 2000 May 15. PMID 10843807
    2. Makorin 1 Regulates Developmental Timing in Drosophila. Tran HT, et al. Mol Cells, 2018 Dec 31. PMID 30396233, Free PMC Article
    3. Hyd ubiquitinates the NF-κB co-factor Akirin to operate an effective immune response in Drosophila. Cammarata-Mouchtouris A, et al. PLoS Pathog, 2020 Apr. PMID 32339205, Free PMC Article
    4. Makorin 1 is required for Drosophila oogenesis by regulating insulin/Tor signaling. Jeong EB, et al. PLoS One, 2019. PMID 31009498, Free PMC Article
    5. Protein degradation of Lsd1 is mediated by Bre1 yet opposed by Lsd1-interacting lncRNAs during fly follicle development. Lin CT, et al. iScience, 2024 May 17. PMID 38655201, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mkrn1 controls embryonic patterning and germ cell formation by specifically activating osk translation, most likely by competing with Bru1 to bind to osk 3' UTR.
      Title: Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation.
    2. Data indicate that Drosophila Makorin RING finger protein 1 gene (Mkrn1) functions in the metabolic regulation of oogenesis.
      Title: Makorin 1 is required for Drosophila oogenesis by regulating insulin/Tor signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification, embryo IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of oskar mRNA translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in pole plasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    makorin 1
    Names
    CG7184-PA
    CG7184-PB
    CG7184-PC
    Mkrn1-PA
    Mkrn1-PB
    Mkrn1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21529959..21533713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079965.4 → NP_524704.1  makorin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524704.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TM0, Q9TVX6, Q9VP20
      Related
      FBpp0078038
      Conserved Domains (2) summary
      smart00356
      Location:20 → 43
      ZnF_C3H1; zinc finger
      cd00162
      Location:213 → 267
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_168922.3 → NP_730653.1  makorin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730653.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TM0, Q9TVX6, Q9VP20
      Related
      FBpp0078039
      Conserved Domains (2) summary
      smart00356
      Location:20 → 43
      ZnF_C3H1; zinc finger
      cd00162
      Location:213 → 267
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    3. NM_001259938.2 → NP_001246867.1  makorin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246867.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TM0, Q9TVX6, Q9VP20
      Conserved Domains (2) summary
      smart00356
      Location:20 → 43
      ZnF_C3H1; zinc finger
      cd00162
      Location:213 → 267
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TVX6 Q9TVX6
    Q9VP20 Q9VP20

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