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    Syt14 Synaptotagmin 14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40544, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Syt14provided by FlyBase
    Official Full Name
    Synaptotagmin 14provided by FlyBase
    Primary source
    FLYBASE:FBgn0261086
    Locus tag
    Dmel_CG9778
    See related
    AllianceGenome:FB:FBgn0261086
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9778; Dmel\CG9778; dsyt14; Syt 14; syt14; SYT14; syt16; Syt16
    Summary
    Predicted to enable phospholipid binding activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 11. Orthologous to several human genes including SYT16 (synaptotagmin 16). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Syt14 in Genome Data Viewer
    Location:
    82A3-82A3; 3-47.1 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4314455..4319069, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (140177..144791, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46140 Neighboring gene Vacuolar protein sorting 24 Neighboring gene Melanization Protease 1 Neighboring gene Suv3 helicase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans. Fukuda M. J Biochem, 2003 May. PMID 12801916
    2. Peptidergic cell-specific synaptotagmins in Drosophila: localization to dense-core granules and regulation by the bHLH protein DIMMED. Park D, et al. J Neurosci, 2014 Sep 24. PMID 25253864, Free PMC Article
    3. Function of Drosophila Synaptotagmins in membrane trafficking at synapses. Quiñones-Frías MC, et al. Cell Mol Life Sci, 2021 May. PMID 33619613, Free PMC Article
    4. Genetic and molecular analysis of the synaptotagmin family. Adolfsen B, et al. Cell Mol Life Sci, 2001 Mar. PMID 11315187, Free PMC Article
    5. Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment. Adolfsen B, et al. J Cell Biol, 2004 Jul 19. PMID 15263020, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c4314530-4314503 mobile_element_type = transposon:1360{}3731

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin 14
    Names
    CG9778-PA
    CG9778-PC
    CG9778-PD
    Syt14-PA
    Syt14-PC
    Syt14-PD
    syt14

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4314455..4319069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275321.1 → NP_001262250.1  synaptotagmin 14, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262250.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VN04
      Conserved Domains (2) summary
      cd08389
      Location:291 → 413
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:446 → 584
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    2. NM_001275320.1 → NP_001262249.1  synaptotagmin 14, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262249.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF61
      Conserved Domains (2) summary
      cd08389
      Location:291 → 413
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:446 → 584
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16

    3. NM_141196.2 → NP_649453.1  synaptotagmin 14, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649453.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VN04
      Related
      FBpp0078597
      Conserved Domains (2) summary
      cd08389
      Location:291 → 413
      C2A_Synaptotagmin-14_16; C2A domain first repeat present in Synaptotagmins 14 and 16
      cd08408
      Location:446 → 584
      C2B_Synaptotagmin-14_16; C2 domain second repeat present in Synaptotagmins 14 and 16
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KF61 A0A0B4KF61
    Q9VN04 Q9VN04

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