Mms19 Mms19 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mms19provided by FlyBase
Official Full Name: Mms19provided by FlyBase
Primary source: FLYBASE:FBgn0037301
Locus tag: Dmel_CG12005
See related: AllianceGenome:FB:FBgn0037301
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12005; Dmel\CG12005; dMMS19; mms19; MMS19; NEST:bs07f08
Summary: Involved in astral microtubule organization; mitotic nuclear division; and positive regulation of organelle organization. Located in several cellular components, including midbody; nucleus; and spindle microtubule. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; larval muscle system; and mesoderm. Orthologous to human MMS19 (MMS19 homolog, cytosolic iron-sulfur assembly component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (5232543..5236288)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (1058265..1062010)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Mms19 promotes spindle microtubule assembly in Drosophila neural stem cells.
Title: Mms19 promotes spindle microtubule assembly in Drosophila neural stem cells.
Mms19 is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase.
Title: Mms19 is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in astral microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein maturation by iron-sulfur cluster transfer	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation by iron-sulfur cluster transfer	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic [4Fe-4S] assembly targeting complex	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle microtubule	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain