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    Tk Tachykinin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41456, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tkprovided by FlyBase
    Official Full Name
    Tachykininprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037976
    Locus tag
    Dmel_CG14734
    See related
    AllianceGenome:FB:FBgn0037976
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14734; Dmel\CG14734; DmTK6; Drm-TK; Drm-TK-1; Drm-TK-2; Drm-TK-3; Drm-TK-4; Drm-TK-5; Drm-TK-6; dtk; dTK; Dtk; DTk; DTK; DTK-1; DTK-2; DTK-3; DTK-4; DTK-5; DTK-6; DTK1; Tachykinin 1; Tachykinin 2; Tachykinin 4; Tachykinin 5; TAP-5; TK; TK-1; Tyk
    Summary
    Enables tachykinin receptor binding activity. Involved in several processes, including adult walking behavior; inter-male aggressive behavior; and positive regulation of hindgut contraction. Located in extracellular space. Is expressed in several structures, including enteroendocrine cell; ganglia; neuromere; sexually-dimorphic neurons; and tachykinin neurons. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    Location:
    87A4-87A4; 3-51 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11994175..12005473, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7819897..7831195, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene midline fasciclin Neighboring gene Ectoderm-expressed 3 Neighboring gene Kelch like family member 18 Neighboring gene GRIP and coiled-coil domain containing 185 kDa Neighboring gene DDB1 and CUL4 associated factor 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and functional characterization of a Drosophila neuropeptide precursor with homology to mammalian preprotachykinin A. Siviter RJ, et al. J Biol Chem, 2000 Jul 28. PMID 10801863
    2. Substitution of conserved glycine residue by alanine in natural and synthetic neuropeptide ligands causes partial agonism at the stomoxytachykinin receptor. Poels J, et al. J Neurochem, 2004 Jul. PMID 15228603
    3. Imaging neuropeptide release at synapses with a genetically engineered reporter. Ding K, et al. Elife, 2019 Jun 26. PMID 31241464, Free PMC Article
    4. Tachykinin-related peptides modulate odor perception and locomotor activity in Drosophila. Winther AM, et al. Mol Cell Neurosci, 2006 Mar. PMID 16289899
    5. Neuronal expression of tachykinin-related peptides and gene transcript during postembryonic development of Drosophila. Winther AM, et al. J Comp Neurol, 2003 Sep 15. PMID 12898611

    See all (171) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Metabolic control of daily locomotor activity mediated by tachykinin in Drosophila.
      Title: Metabolic control of daily locomotor activity mediated by tachykinin in Drosophila.
    2. These results highlight a conserved role for Tachykinin signaling in regulating nociception.
      Title: Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila.
    3. Study identified a small group of sexually dimorphic, FruM+ neurons that promote aggressiveness in Drosophila males but have no influence on male-female courtship behavior. These neurons enhance aggression, at least in part, through the release of a neuropeptide, Drosophila tachykinin.
      Title: Tachykinin-expressing neurons control male-specific aggressive arousal in Drosophila.
    4. The control of DILP5 signaling in the renal tubules by Drosophila tachykinin peptide (DTK) and its receptor DTKR during desiccative, nutritional and oxidative stress, was investigated.
      Title: Insulin production and signaling in renal tubules of Drosophila is under control of tachykinin-related peptide and regulates stress resistance.
    5. The distribution of the Dtk transcript and peptides was analyzed by in situ hybridization and immunocytochemistry during postembryonic development of the central nervous system (CNS) of Drosophila.
      Title: Neuronal expression of tachykinin-related peptides and gene transcript during postembryonic development of Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables neuropeptide hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables signaling receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables tachykinin receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inter-male aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of hindgut contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tachykinin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tachykinin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tachykinin
    Names
    CG14734-PA
    CG14734-PB
    Tachykinin-related
    Tk-PA
    Tk-PB
    neurokinin
    preprotachykinin
    tachykinin-1
    tachykinin-3
    tachykinin-6
    tachykinin-like peptide

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11994175..12005473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275564.2 → NP_001262493.1  tachykinin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262493.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFT7

    2. NM_141884.4 → NP_650141.2  tachykinin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650141.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RJL9, Q8SZ21, Q9NBJ5, Q9VGE8
      Related
      FBpp0081962
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFT7 A0A0B4KFT7
    Q9VGE8.1 Q9VGE8

    Gene LinkOut

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    Other Literature Sources
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