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    Arl6IP1 ADP-ribosylation factor-like 6 interacting protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42027, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arl6IP1provided by FlyBase
    Official Full Name
    ADP-ribosylation factor-like 6 interacting protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0038453
    Locus tag
    Dmel_CG10326
    See related
    AllianceGenome:FB:FBgn0038453
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Al6IP1; ARL6IP1; CG10326; Dmel\CG10326
    Summary
    Involved in endoplasmic reticulum tubular network membrane organization and mitochondrion organization. Is active in endoplasmic reticulum tubular network. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; ganglia; and mesoderm. Used to study hereditary spastic paraplegia and hereditary spastic paraplegia 61. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 61. Orthologous to human ARL6IP1 (ADP ribosylation factor like GTPase 6 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Arl6IP1 in Genome Data Viewer
    Location:
    89D6-89D6; 3-59 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16643605..16645171)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12469327..12470893)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Fasciclin 1 Neighboring gene nonA-like Neighboring gene uncharacterized protein Neighboring gene Chaperonin containing TCP1 subunit 3 Neighboring gene Methyltransferase like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of the Mitochondrial Fission GTPase Drp1 Contributes to Neurodegeneration in a Drosophila Model of Hereditary Spastic Paraplegia. Fowler PC, et al. Brain Sci, 2020 Sep 17. PMID 32957716, Free PMC Article
    2. Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia. Byrne DJ, et al. Acta Neuropathol Commun, 2022 Mar 28. PMID 35346366, Free PMC Article
    3. ER-shaping proteins are required for ER and mitochondrial network organization in motor neurons. Fowler PC, et al. Hum Mol Genet, 2016 Jul 1. PMID 27170313
    4. BTB protein, dKLHL18/CG3571, serves as an adaptor subunit for a dCul3 ubiquitin ligase complex. Fujiyama-Nakamura S, et al. Genes Cells, 2009 Aug. PMID 19624754
    5. A deficiency screen of the 3rd chromosome for dominant modifiers of the Drosophila ER integral membrane protein, Jagunal. Ascencio G, et al. G3 (Bethesda), 2023 Jul 5. PMID 36932646, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum tubular network membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum tubular network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like 6 interacting protein 1
    Names
    Arl6IP1-PA
    Arl6IP1-PB
    CG10326-PA
    CG10326-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16643605..16645171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142313.3 → NP_650570.1  ADP-ribosylation factor-like 6 interacting protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650570.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VES1
      UniProtKB/TrEMBL
      A0A0B4KG41
      Related
      FBpp0082786
      Conserved Domains (1) summary
      pfam02453
      Location:29 → 187
      Reticulon; Reticulon

    2. NM_001275718.1 → NP_001262647.1  ADP-ribosylation factor-like 6 interacting protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262647.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VES1
      UniProtKB/TrEMBL
      A0A0B4KG41
      Conserved Domains (1) summary
      pfam02453
      Location:29 → 187
      Reticulon; Reticulon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KG41 A0A0B4KG41
    Q9VES1.1 Q9VES1

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