Pka-R1 Protein kinase, cAMP-dependent, regulatory subunit type 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pka-R1provided by FlyBase
Official Full Name: Protein kinase, cAMP-dependent, regulatory subunit type 1provided by FlyBase
Primary source: FLYBASE:FBgn0259243
Locus tag: Dmel_CG42341
See related: AllianceGenome:FB:FBgn0259243
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 18304; CdkR; CG12452; CG18677; CG3263; CG42341; Dmel\CG42341; dPKA-RI; DRI; dr[[1]]; pkA; pKA; PKA; PKA R1; pka-R1; PKa-R1; PKA-R1; Pka-RI; PKA-RI; PKAi; PkaR; PKAr; PKAR; PKARI; RI
Old locus tag: Dmel_CG12452; Dmel_CG3263
Summary: Enables cAMP-dependent protein kinase regulator activity. Involved in several processes, including cytoskeleton organization; olfactory learning; and regulation of smoothened signaling pathway. Located in cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut; female germline cell; and ovary. Human ortholog(s) of this gene implicated in Carney complex; acrodysostosis; and primary pigmented nodular adrenocortical disease 1. Orthologous to several human genes including PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 77E8-77F1; 3-47 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20816118..20836048)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (20809218..20829148)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 20818229-20818368 mobile_element_type = transposon:INE-1{}5870
Loc: 20830334-20830385 mobile_element_type = transposon:INE-1{}5871

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cAMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein kinase A catalytic subunit binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP-mediated signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in molting cycle, chitin-based cuticle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	NAS Non-traceable Author Statement more info	PubMed
involved_in oocyte microtubule cytoskeleton polarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of feeding behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	HMP more info	PubMed

Component	Evidence Code	Pubs
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cAMP-dependent protein kinase complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein kinase, cAMP-dependent, regulatory subunit type 1

Names: CG42341-PAA; CG42341-PAB; CG42341-PAC; CG42341-PK; CG42341-PL; CG42341-PM; CG42341-PN; CG42341-PO; CG42341-PP; CG42341-PQ; CG42341-PR; CG42341-PS; CG42341-PT; CG42341-PU; CG42341-PV; CG42341-PW; CG42341-PX; CG42341-PZ; Pka-R1-PAA; Pka-R1-PAB; Pka-R1-PAC; Pka-R1-PK; Pka-R1-PL; Pka-R1-PM; Pka-R1-PN; Pka-R1-PO; Pka-R1-PP; Pka-R1-PQ; Pka-R1-PR; Pka-R1-PS; Pka-R1-PT; Pka-R1-PU; Pka-R1-PV; Pka-R1-PW; Pka-R1-PX; Pka-R1-PZ; cAMP-dependent protein kinase; cAMP-dependent protein kinase 1; cAMP-dependent protein kinase R1; protein kinase A; regulatory subunit of PKA; regulatory subunit of protein kinase A; type I regulatory subunit of cAMP-dependent protein kinase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

20816118..20836048

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001202218.2 → NP_001189147.1 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform AA [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189147.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MRY3

Conserved Domains (2) summary

cd12097
Location:17 → 60

DD_RI_PKA; Dimerization/Docking domain of the Type I Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:132 → 241

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_168875.4 → NP_730573.2 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730573.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V272, A4V277, P16905, Q59E10, Q8IGP3, Q8IPU2, Q8MR47, Q95TK7, Q9VPA6

Conserved Domains (2) summary

cd12097
Location:17 → 60

DD_RI_PKA; Dimerization/Docking domain of the Type I Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:132 → 241

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001202219.2 → NP_001189148.1 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform AB [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189148.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MRY3

Conserved Domains (2) summary

cd12097
Location:17 → 60

DD_RI_PKA; Dimerization/Docking domain of the Type I Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:132 → 241

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_168876.6 → NP_730574.2 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730574.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V272, A4V277, P16905, Q59E10, Q8IGP3, Q8IPU2, Q8MR47, Q95TK7, Q9VPA6

Conserved Domains (2) summary

cd12097
Location:17 → 60

DD_RI_PKA; Dimerization/Docking domain of the Type I Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:132 → 241

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001202220.2 → NP_001189149.1 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform AC [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189149.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MRY3

Conserved Domains (2) summary

cd12097
Location:17 → 60

DD_RI_PKA; Dimerization/Docking domain of the Type I Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:132 → 241

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001014596.3 → NP_001014596.1 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform T [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014596.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V272, A4V277, P16905, Q59E10, Q8IGP3, Q8IPU2, Q8MR47, Q95TK7, Q9VPA6

Conserved Domains (2) summary

cd12097
Location:17 → 60

DD_RI_PKA; Dimerization/Docking domain of the Type I Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:132 → 241

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001014595.3 → NP_001014595.1 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform U [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014595.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V272, A4V277, P16905, Q59E10, Q8IGP3, Q8IPU2, Q8MR47, Q95TK7, Q9VPA6

Conserved Domains (2) summary

cd12097
Location:17 → 60

DD_RI_PKA; Dimerization/Docking domain of the Type I Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:132 → 241

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001014593.3 → NP_001014593.1 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014593.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V272, A4V277, P16905, Q59E10, Q8IGP3, Q8IPU2, Q8MR47, Q95TK7, Q9VPA6

Conserved Domains (2) summary

cd12097
Location:17 → 60

DD_RI_PKA; Dimerization/Docking domain of the Type I Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:132 → 241

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001014594.3 → NP_001014594.1 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014594.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V272, A4V277, P16905, Q59E10, Q8IGP3, Q8IPU2, Q8MR47, Q95TK7, Q9VPA6

Conserved Domains (2) summary

cd12097
Location:17 → 60

DD_RI_PKA; Dimerization/Docking domain of the Type I Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:132 → 241

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_141006.4 → NP_649263.2 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649263.2

Status: REVIEWED

UniProtKB/TrEMBL

C9QP41, Q9VPA7

Conserved Domains (2) summary

COG0664
Location:213 → 339

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:219 → 328

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001202221.1 → NP_001189150.1 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform V [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189150.1

Status: REVIEWED

UniProtKB/TrEMBL

C9QP41, M9MS76

Conserved Domains (2) summary

COG0664
Location:213 → 339

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:219 → 328

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001202217.1 → NP_001189146.1 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform Z [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189146.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MS37

Conserved Domains (1) summary

cd00038
Location:75 → 184

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001014598.2 → NP_001014598.1 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform R [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014598.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P16905

Conserved Domains (2) summary

COG0664
Location:69 → 195

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:75 → 184

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001014597.2 → NP_001014597.1 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform S [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014597.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P16905

Conserved Domains (2) summary

COG0664
Location:46 → 172

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:52 → 161

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001202216.1 → NP_001189145.1 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform X [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189145.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MS72

Conserved Domains (1) summary

cd00038
Location:52 → 161

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_079465.4 → NP_524189.2 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524189.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P16905

Conserved Domains (2) summary

COG0664
Location:46 → 172

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:52 → 161

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001202215.1 → NP_001189144.1 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform W [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189144.1

Status: REVIEWED

UniProtKB/TrEMBL

H1UUF3

Conserved Domains (1) summary

cd00038
Location:77 → 186

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_168877.2 → NP_730576.1 protein kinase, cAMP-dependent, regulatory subunit type 1, isoform Q [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730576.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P16905

Conserved Domains (1) summary

cd00038
Location:77 → 186

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...