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    nAChRalpha6 nicotinic Acetylcholine Receptor alpha6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34304, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nAChRalpha6provided by FlyBase
    Official Full Name
    nicotinic Acetylcholine Receptor alpha6provided by FlyBase
    Primary source
    FLYBASE:FBgn0032151
    Locus tag
    Dmel_CG4128
    See related
    AllianceGenome:FB:FBgn0032151
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AChRalpha6; alpha6; BcDNA:GH01410; CG4128; CT13662; dalpha6; Dalpha6; das; Dmel\CG4128; nAChR; nAChR alpha 6; nAChR-alpha30D; nAChRalpha; nAChRalpha-30D; nAChRAlpha-30D; nAChralpha6; nAchR_alpha6; nAcRalpha-30D; nACRalpha-30D; rsn
    Summary
    Contributes to acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including cholinergic synaptic transmission; muscle cell cellular homeostasis; and response to insecticide. Located in membrane. Part of acetylcholine-gated channel complex. Is expressed in adult head; antennal mechanosensory and motor center; gnathal ganglion; and mushroom body calyx. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; esophagus squamous cell carcinoma; respiratory system cancer (multiple); and schizophrenia. Orthologous to human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nAChRalpha6 in Genome Data Viewer
    Location:
    30D1-30E1; 2-36 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9793317..9886250, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9793317..9886250, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43766 Neighboring gene long non-coding RNA:CR44701 Neighboring gene uncharacterized protein Neighboring gene FK506-binding protein 59kD

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A CRISPR/Cas9 mediated point mutation in the alpha 6 subunit of the nicotinic acetylcholine receptor confers resistance to spinosad in Drosophila melanogaster. Zimmer CT, et al. Insect Biochem Mol Biol, 2016 Jun. PMID 27117524, Free PMC Article
    2. Limitations of RNAi of α6 nicotinic acetylcholine receptor subunits for assessing the in vivo sensitivity to spinosad. Rinkevich FD, et al. Insect Sci, 2013 Feb. PMID 23955830
    3. Tissue-specific transcriptome analyses in Drosophila provide novel insights into the mode of action of the insecticide spinosad and the function of its target, nAChRα6. Martelli F, et al. Pest Manag Sci, 2023 Oct. PMID 37248207
    4. Selection and characterization of spinetoram resistance in field collected Drosophila melanogaster. Scott JG, et al. Pestic Biochem Physiol, 2023 Aug. PMID 37532361
    5. Enrichment of Membrane Proteins for Downstream Analysis Using Styrene Maleic Acid Lipid Particles (SMALPs) Extraction. Dirnberger B, et al. Bio Protoc, 2023 Aug 5. PMID 37575399, Free PMC Article

    See all (137) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Temporal regulation of nicotinic acetylcholine receptor subunits supports central cholinergic synapse development in Drosophila.
      Title: Temporal regulation of nicotinic acetylcholine receptor subunits supports central cholinergic synapse development in Drosophila.
    2. The introduced G275E mutation of the nAChR alpha6 subunit confers strong resistance in Drosophila to spinosad, with the LC50 increasing from around 5 mg L-1 to 335 mg L-1.
      Title: A CRISPR/Cas9 mediated point mutation in the alpha 6 subunit of the nicotinic acetylcholine receptor confers resistance to spinosad in Drosophila melanogaster.
    3. In addition to the formation of homomeric nAChR complexes, evidence has been obtained from both radioligand binding and co-immunoprecipitation studies for the co-assembly of Dalpha6 and Dalpha7 into heteromeric cell surface complexes
      Title: Molecular characterization of Dalpha6 and Dalpha7 nicotinic acetylcholine receptor subunits from Drosophila: formation of a high-affinity alpha-bungarotoxin binding site revealed by expression of subunit chimeras.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to acetylcholine-gated monoatomic cation-selective channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to insecticide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of acetylcholine-gated channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of acetylcholine-gated channel complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nicotinic acetylcholine receptor alpha6
    Names
    CG4128-PA
    CG4128-PB
    CG4128-PC
    CG4128-PD
    CG4128-PE
    CG4128-PG
    CG4128-PH
    Dalpha6
    alpha6 nicotinic acetylcholine receptor subunit
    nAChRalpha6-PA
    nAChRalpha6-PB
    nAChRalpha6-PC
    nAChRalpha6-PD
    nAChRalpha6-PE
    nAChRalpha6-PG
    nAChRalpha6-PH
    nicotinic acetylcholine receptor 30D
    nicotinic acetylcholine receptor alpha 30D
    resistance to spinosyn
    resistant to spinosyns

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9793317..9886250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135472.6 → NP_609316.4  nicotinic acetylcholine receptor alpha6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609316.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPE2, Q8T7S1
      Related
      FBpp0079504
      Conserved Domains (2) summary
      TIGR00860
      Location:11 → 488
      LIC; Cation transporter family protein
      cd18997
      Location:55 → 236
      LGIC_ECD_nAChR; extracellular domain of nicotinic acetylcholine receptor

    2. NM_205953.3 → NP_995675.1  nicotinic acetylcholine receptor alpha6, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995675.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTF8, Q8T7R9
      Conserved Domains (2) summary
      TIGR00860
      Location:11 → 517
      LIC; Cation transporter family protein
      cd18997
      Location:55 → 236
      LGIC_ECD_nAChR; extracellular domain of nicotinic acetylcholine receptor

    3. NM_001201835.3 → NP_001188764.1  nicotinic acetylcholine receptor alpha6, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188764.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTF9, Q8T7S2
      Conserved Domains (2) summary
      TIGR00860
      Location:11 → 488
      LIC; Cation transporter family protein
      cd18997
      Location:55 → 236
      LGIC_ECD_nAChR; extracellular domain of nicotinic acetylcholine receptor

    4. NM_205952.3 → NP_995674.1  nicotinic acetylcholine receptor alpha6, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995674.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTF7, Q8T7S0
      Conserved Domains (2) summary
      TIGR00860
      Location:11 → 503
      LIC; Cation transporter family protein
      cd18997
      Location:55 → 251
      LGIC_ECD_nAChR; extracellular domain of nicotinic acetylcholine receptor

    5. NM_001273373.2 → NP_001260302.1  nicotinic acetylcholine receptor alpha6, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260302.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFD8, Q8T7S2
      Conserved Domains (2) summary
      TIGR00860
      Location:11 → 488
      LIC; Cation transporter family protein
      cd18997
      Location:55 → 236
      LGIC_ECD_nAChR; extracellular domain of nicotinic acetylcholine receptor

    6. NM_205951.2 → NP_995673.1  nicotinic acetylcholine receptor alpha6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995673.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTF9, Q8T7S2
      Conserved Domains (2) summary
      TIGR00860
      Location:11 → 488
      LIC; Cation transporter family protein
      cd18997
      Location:55 → 236
      LGIC_ECD_nAChR; extracellular domain of nicotinic acetylcholine receptor

    7. NM_164874.3 → NP_723494.2  nicotinic acetylcholine receptor alpha6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723494.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T7S1, Q8T7S3, Q9VL79
      Related
      FBpp0079505
      Conserved Domains (2) summary
      TIGR00860
      Location:11 → 488
      LIC; Cation transporter family protein
      cd18997
      Location:55 → 236
      LGIC_ECD_nAChR; extracellular domain of nicotinic acetylcholine receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFD8 M9PFD8
    Q7KTF7 Q7KTF7
    Q7KTF8 Q7KTF8
    Q7KTF9 Q7KTF9
    Q86MN8 Q86MN8
    Q8IPE2 Q8IPE2
    Q8T7R9 Q8T7R9
    Q8T7S0 Q8T7S0
    Q8T7S1 Q8T7S1
    Q8T7S2 Q8T7S2
    Q95TD0 Q95TD0
    Q9VL79 Q9VL79

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