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    sbb scribbler [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44027, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sbbprovided by FlyBase
    Official Full Name
    scribblerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0285917
    Locus tag
    Dmel_CG5580
    See related
    AllianceGenome:FB:FBgn0285917
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bks; Bks; Brakeless; CG5580; disc6; Dmel\CG5580; GM04742; Group IIa; l(2)04440; mtv; Mtv; plt; Sbb; SBb; sbb/mtv
    Summary
    Enables transcription corepressor activity. Involved in several processes, including axonogenesis; negative regulation of transcription by RNA polymerase II; and wing disc development. Located in nucleus. Is expressed in several structures, including anterior-posterior subdivision of organism; ganglia; imaginal disc; mesoderm; and somatic cell of testis. Orthologous to human ZNF608 (zinc finger protein 608) and ZNF609 (zinc finger protein 609). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sbb in Genome Data Viewer
    Location:
    55C2-55C4; 2-85 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18278198..18357296, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14165703..14244801, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44421 Neighboring gene presenilin enhancer Neighboring gene Otefin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Transport and Golgi organization 8 Neighboring gene long non-coding RNA:CR42736 Neighboring gene Bomanin Tailed 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Serotonergic neuronal death and concomitant serotonin deficiency curb copulation ability of Drosophila platonic mutants. Yilmazer YB, et al. Nat Commun, 2016 Dec 13. PMID 27958269, Free PMC Article
    2. Abnormal turning behavior in Drosophila larvae. Identification and molecular analysis of scribbler (sbb). Yang P, et al. Genetics, 2000 Jul. PMID 10880478, Free PMC Article
    3. Alteration of wing size through over-expression of scribbler isoforms. LaJeuensse D. Fly (Austin), 2010 Oct-Dec. PMID 20798603
    4. Turning behavior in Drosophila larvae: a role for the small scribbler transcript. Suster ML, et al. Genes Brain Behav, 2004 Oct. PMID 15344921
    5. Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31. Groth AC, et al. Genetics, 2004 Apr. PMID 15126397, Free PMC Article

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data provide support for a Brakeless activator function that regulates transcription by interacting with Med19
      Title: The Brakeless co-regulator can directly activate and repress transcription in early Drosophila embryos.
    2. Sbb is associated with wing size.
      Title: Alteration of wing size through over-expression of scribbler isoforms.
    3. Scribble is part of the Stbm/Vang PCP complex and further suggest that it might act as an effector of Stbm/Vang during PCP establishment.
      Title: The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors.
    4. Brakeless is recruited to the Kr and kni cis-regulatory DNA modules, and represses transcription when tethered to DNA.
      Title: Drosophila brakeless interacts with atrophin and is required for tailless-mediated transcriptional repression in early embryos.
    5. both LRR and PDZ domains are important for the proper localization and function of Scribble in neuroblasts
      Title: Scribble protein domain mapping reveals a multistep localization mechanism and domains necessary for establishing cortical polarity.
    6. The neoplastic tumor suppressor gene scribble, via the activity of the LRR, governs proliferation primarily by regulating apicobasal polarity.
      Title: Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble.
    7. Studies focused on the smaller of the two scribbler transcripts and show that its pan-neural expression during early larval life, but not in later larval life, restores wild type turning behavior.
      Title: Turning behavior in Drosophila larvae: a role for the small scribbler transcript.
    8. The cytoarchitectural suppressor gene scribble interacts with cell adhesion, signaling, cytoskeletal, and chromatin remodeling genes to negatively regulate cyclin E or S-phase entry.
      Title: A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila.
    9. mutations in Atro and Sbb have similar phenotypes, including upregulation of the same genes in imaginal discs, which suggests that Sbb cooperates with Atro to provide repressive activity
      Title: Genetic interactions among scribbler, Atrophin and groucho in Drosophila uncover links in transcriptional repression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon target recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval locomotory behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wing disc dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    scribbler
    Names
    CG5580-PC
    CG5580-PD
    CG5580-PE
    CG5580-PF
    CG5580-PG
    CG5580-PH
    CG5580-PJ
    brakeless
    master of thickveins
    mother of thick-vein
    platonic
    sbb-PC
    sbb-PD
    sbb-PE
    sbb-PF
    sbb-PG
    sbb-PH
    sbb-PJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18278198..18357296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169720.2 → NP_001163191.1  scribbler, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163191.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGL0, Q9GRA9
      Conserved Domains (1) summary
      PRK10856
      Location:1143 → 1245
      PRK10856; cytoskeletal protein RodZ; Provisional

    2. NM_001169718.3 → NP_001163189.1  scribbler, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163189.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZB50, Q9GRA9, Q9N693
      Conserved Domains (1) summary
      PRK10856
      Location:1133 → 1235
      PRK10856; cytoskeletal protein RodZ; Provisional

    3. NM_001274145.1 → NP_001261074.1  scribbler, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261074.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEU2, Q9GRA9
      Conserved Domains (1) summary
      PRK10856
      Location:1143 → 1245
      PRK10856; cytoskeletal protein RodZ; Provisional

    4. NM_079939.5 → NP_524678.3  scribbler, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524678.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZB50, Q9GRA9, Q9N693
      Conserved Domains (1) summary
      PRK10856
      Location:1133 → 1235
      PRK10856; cytoskeletal protein RodZ; Provisional

    5. NM_206161.3 → NP_995883.1  scribbler, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995883.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZB51, Q9NHQ0

    6. NM_001169719.2 → NP_001163190.1  scribbler, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163190.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NBL3, Q9NBW0

    7. NM_206162.4 → NP_995884.1  scribbler, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995884.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NBL3, Q9NBW0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEU2 A0A0B4KEU2
    A1ZB51 A1ZB51
    E1JGL0 E1JGL0
    Q8SX80 Q8SX80
    Q8T9H1 Q8T9H1
    Q9GRA9 Q9GRA9
    Q9N693 Q9N693
    Q9NBL3 Q9NBL3
    Q9NBW0 Q9NBW0
    Q9NGW5 Q9NGW5
    Q9NHQ0 Q9NHQ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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